A Random Comparative Study of Terbinafine Versus Griseofulvin in Patients with Tinea Capitis in Western China

Abstract

Data from the clinical trial and in vitro antifungal activity indicated that terbinafine is efficacious and well tolerated in the treatment for Trichophyton infections (T. violaceum; Arthroderma vanbreuseghemii; and T. tonsurans) of the scalp, i.e., a 2- to 4-week course of terbinafine is as effective as a 4-week course of griseofulvin; in fact, a 2-week course of terbinafine is sufficient. Terbinafine is an effective alternative to griseofulvin against tinea capitis of Trichophyton infections.

Tinea capitis in children: a systematic review of management

“…). The most common organisms found in each continent were T. violaceum in Africa, M. canis in Asia, M. canis in Europe, T. tonsurans in North America and M. canis in South America (Fig. ).…”

“…The most common hair sample collection method was the Wood's light examination/light microscopic examination (9/18) (Table ). Across all studies, five oral antifungals (terbinafine, griseofulvin, itraconazole, ketoconazole and fluconazole) were examined in 3998 children . A few included studies also evaluated the efficacy and safety of combinations of oral and topical therapies across a total of 833 treated children and 25 children used only topical therapies …”

“…Terbinafine was evaluated in twelve included studies using weighted averages with a pooled total of 1592 children (Table ). Using the predefined definition of mycological cure (negative mycological testing) and after one or 2 weeks of treatment, terbinafine had a weighted average of 53.8% (57/106) children mycologically cured.…”

Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic review

“…Directed antimicrobial therapy. Tinea capitis-Moderate quality evidence for griseofulvin, terbinafine and fluconazole having similar efficacy for tinea capitis (1B) [70][71][72][73]. Tinea capitis is difficult to treat, takes several months and mycological cure is challenging.…”

“…In addition, all used ketoconazole 2% shampoo and prednisolone prescribed for kerion [72]. From China, low-quality cluster RCT evidence confirmed griseofulvin daily for 4 weeks or terbinafine daily for 2-4 weeks performed similarly [73].…”