A Raman spectroscopic study of the diclofenac sodium–β-cyclodextrin interaction

Iliescu, T.; Baia, Monica; Miclăuş, Vasile

doi:10.1016/j.ejps.2004.05.003

Cited by 87 publications

(54 citation statements)

References 25 publications

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“…Such a large shift for ω CON (≈ 30 cm −1 ) is rather unusual in the study of the complexation processes where, generally, smaller variations are observed. 7,8,9 From the above results one might infer that it is the amide C=O group of IMC (and the neighboring atoms) to be mainly affected by the inclusion process. However, in order to understand the precise way in which such atoms are influenced by complexation, other possible effects should be discussed.…”

Section: Resultsmentioning

confidence: 99%

Vibrational properties of inclusion complexes: The case of indomethacin-cyclodextrin

Rossi

Verrocchio

Viliani

et al. 2006

The Journal of Chemical Physics

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Vibrational properties of inclusion complexes with cyclodextrins are studied by means of Raman spectroscopy and numerical simulation. In particular, Raman spectra of the non-steroidal, antiinflammatory drug indomethacin undergo notable changes in the energy range between 1600 and 1700 cm −1 when inclusion complexes with cyclodextrins are formed. By using both ab initio quantum chemical calculations and molecular dynamics, we studied how to relate such changes to the geometry of the inclusion process, disentangling single-molecule effects, from changes in the solid state structure or dimerization processes.

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Section: Resultsmentioning

confidence: 99%

Vibrational properties of inclusion complexes: The case of indomethacin-cyclodextrin

Rossi

Verrocchio

Viliani

et al. 2006

The Journal of Chemical Physics

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“…In addition, Raman spectroscopy is typically noninvasive and nondestructive, making it an excellent method for the analysis of intact dosage forms. In a number of studies, [18][19][20][21][22][23][24] Raman technique exhibits its potential for investigating complex geometries and characterizing the formation of intermolecular hydrogen bonding between the guest and the host, of which are not readily accessible by other spectroscopic techniques. It is of interest to investigate whether this technique can be used for detecting the complexation of drugs present in solid pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Detecting and Identifying the Complexation of Nimodipine with Hydroxypropyl-β-Cyclodextrin Present in Tablets by Raman Spectroscopy

Yang

et al. 2008

Journal of Pharmaceutical Sciences

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“…[30][31][32][33] This technique presents a clear advantage when compared to the analogous FTIR spectra due to the relative silence of the cyclodextrin in the Raman spectra, which does not show any relevant overlap in the spectral patterns, permitting a better comparison between the free and the included molecule. 34 Raman spectra showed a decrease in the peak intensity in the 6CN10:HP-β-CD complex when compared with the 6CN10 and with the 6CN10 and HP-β-CD physical mixture spectra (Figure 4).…”

Section: Fourier Transform Infrared and Raman Spectroscopymentioning

confidence: 99%

Improvement of Solubility and Antifungal Activity of a New Aminothiophene Derivative by Complexation with 2-Hydroxypropyl-β-cyclodextrin

Eleamen¹,

Costa²,

Lima-Neto³

et al. 2016

Journal of the Brazilian Chemical Society

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This study aimed to prepare a complex of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and 6CN10, a poorly water soluble 2-aminothiophene derivative with antifungal properties, by freeze-drying technique. The complex was characterized by thermal analysis, infrared/Raman spectroscopy, X-ray diffraction and scanning electron microscopy. In addition, we used the data of the phase solubility study, 1 H, and 2D NMR spectroscopy and molecular modeling in order to investigate the interactions between 6CN10 and HP-β-CD. The apparent solubility of 6CN10 with HP-β-CD increased more than 29 fold. The phase solubility assay in water at 25 ºC showed an A P -type curve, with an apparent stability constant K 1:1 and K 1:2 of 96 and 0.1989 M -1 , respectively. The results of IR, NMR and docking indicate that 6CN10 is able to form complexes with HP-β-CD (1:1 and 1:2 stoichiometric ratios), generating the formation of inclusion and preferably, non-inclusion complexes. The antifungal activity against Cryptococcus neoformans demonstrated the superior performance of the complex (46.66 μg mL -1 ) when compared with the free drug (166.66-333.33 μg mL -1 ). The present study provides useful information for the potential application of complexation with low soluble compounds and about the type of complex formation between 6CN10 and HP-β-CD.

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A Raman spectroscopic study of the diclofenac sodium–β-cyclodextrin interaction

Cited by 87 publications

References 25 publications

Vibrational properties of inclusion complexes: The case of indomethacin-cyclodextrin

Vibrational properties of inclusion complexes: The case of indomethacin-cyclodextrin

Detecting and Identifying the Complexation of Nimodipine with Hydroxypropyl-β-Cyclodextrin Present in Tablets by Raman Spectroscopy

Improvement of Solubility and Antifungal Activity of a New Aminothiophene Derivative by Complexation with 2-Hydroxypropyl-β-cyclodextrin

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