This paper presents a new extremely low-voltage low-power bulk-driven (BD) operational transconductance amplifier (OTA) realized for low frequency biosignal processing. The CMOS structure of the OTA utilizes bulk-driven and self-cascode techniques in the subthreshold region, supporting the operation with the supply voltage (V DD ) as the threshold voltage (V TH ) of a single MOS transistor, i.e., V DD = V TH = 0.5 V, while offering nano power consumption (31.3 nW for 15 nA nominal setting current). Using the extremely low-voltage and low-power OTA in biosignal processing enables extending the lifetime of applications that are powered by battery or energy harvesting sources. The OTA has a 54.7 dB low frequency gain, 6.18 kHz gain bandwidth and 75 • phase margin at 15 pF load capacitance. The proposed OTA has been used to realize a bandpass filter (BPF) with adjustable gain for electrocardiogram (ECG) signal processing. The higher cutoff frequency of the BPF is adjustable electronically by a setting current and the BPF's gain can be adjusted by capacitors value. The total harmonic distortion (THD) of the BPF is −53.56 dB, the input integrated input-referred voltage noise is 17.9 µV rms , the common mode rejection ratio (CMRR) is 75 dB and the power supply rejection ratio (PSRR) is 87.7 dB. The BPF was designed in the Cadence program using 0.18 µm CMOS technology from TSMC. The simulation results agree with the presented theory.INDEX TERMS Operational transconductance amplifier (OTA), bulk-driven, band-pass filter, low-voltage, low-power CMOS. FABIAN KHATEB received the M.Sc. and Ph.D. degrees in electrical engineering and communication and the M.Sc. and Ph.D. degrees in business and management from the