A radiopharmaceuticals schedule for imaging in paediatrics

Piepsz, Amy; Hahn, Klaus; Roca, Isabel; Ciofetta, G; Toth, Gellert; Gordon, Isky; Kolínská, J; Gwidlet, J

doi:10.1007/bf00811439

Cited by 140 publications

(32 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The EANM guidelines started with a report by Piepsz et al, who presented a radiopharmaceutical schedule for an adult-to-pediatric scaling factor that was based on body surface area calculated from patient weight based on the practice at 4 institutions (20). These scaling factors were subsequently studied by Jacobs et al, who investigated whether the factors gave weight-independent effective doses or weight-independent counting rates (21).…”

Section: Eanm Dosage Card (2007 and 2014)mentioning

confidence: 99%

“…All 3 guidelines adjust the administered activity according to patient weight. Although the use of weight-based activity adjustment has been debated, it has remained a popular approach (2,20,24,25). The North American Consensus Guidelines recommend linear scaling by weight because this results in a small variation in counts per unit area from infancy to adolescence.…”

Section: Comparison Of the Guidelines And A Move Toward Harmonizationmentioning

confidence: 99%

See 1 more Smart Citation

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

et al. 2016

View full text Add to dashboard Cite

The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI are to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the standardization of administered activities in pediatric nuclear medicine. It was decided to divide the final report of this project into 2 parts. Part 1 was published in this journal in the spring of 2015. This article presents part 2 of the final report. It discusses current standards for administered activities in children and adolescents that have been developed by various professional organizations. It also presents an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of 313 nuclear medicine clinics and centers from 29 countries. Lastly, it provides recommendations for a path toward global standardization of the administration of radiopharmaceuticals in children. Int he summer of 2012, several international organizations directly involved in the practice and science of nuclear medicine decided to engage in a project of common interest for the betterment of the field worldwide. The underlying objectives were to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. This endeavor was named the Nuclear Medicine Global Initiative (NMGI) and includes societies from various countries as well as several multinational organizations in the field of nuclear medicine (Table 1).The group decided that the first NMGI project would be to consider the issues involved in the standardization of administered activities in pediatric nuclear medicine. Part 1 of this report described the reasons for the choice of project (1). It also provided a review of the value of pediatric nuclear medicine, the current understanding of the carcinogenic risk of radiation as it pertains to the administration of radiopharmaceuticals in children, and the application of dosimetric models in children. Gaps in current knowledge on these topics were also discussed. A listing of pertinent educational and reference resources, available in print and online, was provided and described.

show abstract

Section: Eanm Dosage Card (2007 and 2014)mentioning

confidence: 99%

Section: Comparison Of the Guidelines And A Move Toward Harmonizationmentioning

confidence: 99%

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The patients were administered our standard institutional activities of 99m Tc-methylene diphosphonate based on a body surface area nomogram (6). For all patient weights, our institutional activities were greater than the suggested activities based on the NACG and EANM Dosage Card.…”

Section: Methodsmentioning

confidence: 99%

Dose Optimization of the Administered Activity in Pediatric Bone Scintigraphy: Validation of the North American Consensus Guidelines

et al. 2015

View full text Add to dashboard Cite

The 2010 North American Consensus Guidelines (NACG) for pediatric administered doses and the European Association of Nuclear Medicine (EANM) Dosage Card guidelines recommend lower activities than those administered at our institution. We compared the quality of the lower-activity images with the higher-activity images to determine whether the reduction in counts affects overall image quality. Methods: Twenty patients presenting to our pediatric radiology department for bone scintigraphy were evaluated. Their mean weight was 20 kg. The patients were referred for oncologic (n 5 10), infectious/inflammatory (n 5 5), and pain (n 5 5) evaluation. Dynamic anterior and posterior images were acquired for 5 min for each patient. Data were subsampled to represent different administered activities corresponding to the activities recommended by the NACG and the EANM Dosage Card. Images were evaluated twice, first for diagnostic quality and then for acceptability for daily clinical use. Results: There was no statistically significant difference in the diagnostic quality of the images from any of the 3 protocols. Pathologic uptake was correctly identified independent of the administered activity, although there was a single false-positive result for an EANM image. When images were subjectively evaluated as acceptable for daily clinical use, there was a slight preference for the higher-activity images over the NACG (P 5 0.04). Conclusion: The recommended administered activities of the NACG produce images of diagnostic quality while reducing patient radiation exposure.

show abstract

“…Urethral catheterization was used selectively. 99m Tc-MAG-3 was used with a minimum dose of 1.0 mCi and the total dose was calculated according to the patient weight (Doses adapted from the report of Pediatric Task Group European Association Nuclear Medicine [7]). Children were imaged in the supine position.…”

Section: Methodsmentioning

confidence: 99%

Results of a practical protocol for management of prenatally detected hydronephrosis due to ureteropelvic junction obstruction

et al. 2008

View full text Add to dashboard Cite

Pyeloplasty may be performed safely in infants when indicated; however, the majority of children with UPJO can be managed conservatively. Spontaneous resolution of hydronephrosis and/or favorable prognosis was encountered in 87% of conservatively managed RU. The use of a standard US grading system, selective utilization of follow-up renal function testing, and parental compliance are important factors in successful management.

show abstract

A radiopharmaceuticals schedule for imaging in paediatrics

Cited by 140 publications

References 2 publications

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2—Current Standards and the Path Toward Global Standardization

Dose Optimization of the Administered Activity in Pediatric Bone Scintigraphy: Validation of the North American Consensus Guidelines

Results of a practical protocol for management of prenatally detected hydronephrosis due to ureteropelvic junction obstruction

Contact Info

Product

Resources

About