A Radionuclide Generator and Infusion System for Pharmaceutical Quality Rb-82

Positron emission tomographic measurement of blood‐to‐brain and blood‐to‐tumor transport of 82Rb: The effect of dexamethasone and whole‐brain radiation therapy

“…For before-and-after studies, only 6 to 10 minutes are required for isotopic decay, and therefore corrections for residual radioactivity are not required. Ionic 82Rb (specific activity, 1.5 X lo5 C i / p~) was eluted with normal saline from a portable Squibb generator (12) and infused directly into patients by means of a Harvard pump. The radiation absorbed dose for 82Rb has been estimated by Kearfott C191: per administered millicurie, the kidney (critical organ), heart, and total body receive 19, 13, and 1.6 mrad, respectively.…”

Generators of Ultra-Short Lived Radionuclides for Routine Clinical Applications

“…At pH 7, the distribution coefficients of Sr and Rb on this exchanger were found to be 20.000 ml/g and 1 ml/g respectively [18]. The same conclusion was drawn by NEYRINCKX et al in a similar study [19], From these results, a generator providing 82 Rb in a bolus was developed by GENNARO et al [20], while a generator for continuous elution was designed at Liege [21 ]. 82 Rb is eluted by a 0.9% NaCl solution.…”

“…Such a simple procedure can be easily and safely repeated be means of the inexpensive, automated multimode perfusion pump developed at liege (CRC) for the reproducible operation of the Ir-191m generator or by means of the more sophisticated microprocessor-controlled elution system used at the Donner Laboratory [44] or at the Squibb Institute for Medical Research [20].…”

Accelerator-Derived Radionuclide Generators

“…Instrumentation for the elution and delivery from the 82 Sr generator to man have been described by GENNARO [63] and YANO etal. [64,65].…”