A RADIOMIMETIC EFFECT OF TRIETHYLENEMELAMINE ON REPRODUCTION IN THE MALE RAT123

Steinberger, Emil; Nelson, Warren O.; Boccabella, Anthony V.; Dixon, William J.

doi:10.1210/endo-65-1-40

Cited by 31 publications

(16 citation statements)

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“…The findings of azoospermia and of severe depletion of germinal elements on testicular biopsy in 70% of the men studied are in keeping with the known destructive effects of alkylating agents in rodents (8)(9)(10) and man (7,11). This particular susceptibility of the germinal tissue to alkylating agents and antimetabolites probably is a consequence of the rapid cell turnover present in the spermatogenic cells of the seminiferous …”

Section: Introductionsupporting

confidence: 76%

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Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Thiel¹,

Sherins²,

Myers³

et al. 1972

J. Clin. Invest.

193

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A B S T R A C T The interaction of the testis and gonadotropin secretion was studied in 15 men surviving chemotherapy for lymphoma. Azoospermia and complete destruction of all testicular germinal elements were present in 10 of the 15 men; however, Sertoli cells and Leydig cells were present. In these 10 men plasma follicle-stimulating hormone (FSH) levels were fourfold higher than in normal men of similar age whereas luteinizing hormone (LH) levels were normal. In contrast, both FSH and LH were normal in the remaining five men. Three had a full complement of spermatogenic tissue on biopsy and normal sperm concentrations. The other two men were azoospermic; one demonstrated full spermatogenesis in 30% of his tubules; the other had only a few spermatogonia in all tubules. In those patients with lower levels of gonadotropins pituitary insufficiency was excluded by the demonstration of appropriate responsiveness of FSH and LH to clomiphene administration. Similarly, Leydig cell function was normal since plasma testosterone was within the normal range in 13 of the 15 men and only slightly decreased in two. Thus, following chemotherapy, testicular damage was restricted to the germinal tissue, and this in turn was associated with a selective increase in FSH. The source of the FSH inhibitor is either the Sertoli cell or early germinal elements. However, since FSH levels are only half as high as those reported for castrate men, other testicular factors may modify FSH secretion.

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Section: Introductionsupporting

confidence: 76%

“…Earlier work suggested that damage to the testis primarily affecting the germinal epithelium was associated with increased excretion of FSH (2)(3)(4)(5)(6). Since antitumor drugs, particularly the alkylating agents, are known to induce destruction of germinal tissue (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Thiel¹,

Sherins²,

Myers³

et al. 1972

J. Clin. Invest.

193

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“…It thus appears that the duration of treatment rather than dose is critical for the antispermatogenic efficacy of this compound. The nature of histological changes in the testis of the rhesus monkey after Tretamine administration is comparable to those reported for rats given high doses of this compound (Steinberger et al, 1959). Spermatogenesis is arrested at the spermatogonial stage and the subsequent stages are depleted by maturation.…”

Section: Introductionsupporting

confidence: 76%

“…1, Fig. 3 (Paget et al, 1961;Bock & Jackson, 1957;Steinberger et al, 1959;Jackson et al, 1961), do indeed exert one or the other type of effect on the genital organs of male rhesus monkeys.…”

Section: Introductionmentioning

confidence: 89%

“…Such antifertility effect is believed to be due to intra¬ uterine death of foetuses and pre-implantation ova in females inseminated by males treated with this compound (Steinberger, Nelson, Boccabella & Dixon, 1959). Higher doses produce a biphasic sterility pattern (Bock & Jackson, 1957) and destruction of spermatogonia followed by maturation depletion of the seminiferous epithelium (Steinberger et al, 1959). In dogs, intravenous infusion in small doses causes arrest of spermatogenesis with desquamation and pyknosis of the seminiferous epithelial elements and formation of multinucleate giant cells (Hendry, Homer, Rose & Walpole, 1951).…”

Section: Introductionmentioning

confidence: 99%

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