A radiological score for the assessment of tuberculosis progression: Validation in mouse models

Ortega-Gil, Ana; Muñoz-Barrutia, Arrate; Roca, José J. Rifón; Guijarro-Lopez, Laura; Vaquero, J.J.

doi:10.1016/j.tube.2020.101918

Cited by 1 publication

(2 citation statements)

References 30 publications

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“…In the case of threshold segmentation, these protocols and calibrations allow for working with an accurate window level for thresholding, such as in clinical imaging. In fact, the intensity window applied in this project (−700/−300 HU) is the same as in previous studies in human medicine [ 8 , 12 , 19 ] or preclinical imaging [ 33 ] although some other authors used different HU values for lung and air thresholds, such as Elgeti et al, who used a wider range (−950/−280 HU). Ruscitti and collaborators included as lung tissue all the voxels within −900 and −500 HU.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the technical part of the experiment, the acquisition protocol used during this experiment is similar to that described in other rodent imaging publications [ 11 , 14 , 16 , 24 , 32 , 33 , 34 , 35 , 36 , 37 ]. Regarding the results for the negative control animals in the different pathologic models, no differences were observed after comparing the results from the different used microCT systems.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lung Volume Calculation in Preclinical MicroCT: A Fast Geometrical Approach

Camara

Pujol²,

Jiménez

et al. 2022

J. Imaging

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In this study, we present a time-efficient protocol for thoracic volume calculation as a proxy for total lung volume. We hypothesize that lung volume can be calculated indirectly from this thoracic volume. We compared the measured thoracic volume with manually segmented and automatically thresholded lung volumes, with manual segmentation as the gold standard. A linear regression formula was obtained and used for calculating the theoretical lung volume. This volume was compared with the gold standard volumes. In healthy animals, thoracic volume was 887.45 mm3, manually delineated lung volume 554.33 mm3 and thresholded aerated lung volume 495.38 mm3 on average. Theoretical lung volume was 554.30 mm3. Finally, the protocol was applied to three animal models of lung pathology (lung metastasis and transgenic primary lung tumor and fungal infection). In confirmed pathologic animals, thoracic volumes were: 893.20 mm3, 860.12 and 1027.28 mm3. Manually delineated volumes were 640.58, 503.91 and 882.42 mm3, respectively. Thresholded lung volumes were 315.92 mm3, 408.72 and 236 mm3, respectively. Theoretical lung volume resulted in 635.28, 524.30 and 863.10.42 mm3. No significant differences were observed between volumes. This confirmed the potential use of this protocol for lung volume calculation in pathologic models.

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