1973
DOI: 10.1016/0003-9969(73)90022-8
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A radioautographic study of deoxyribonucleic acid synthesis in embryonic rat palatal shelf epithelium with reference to the concept of programmed cell death

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Cited by 92 publications
(33 citation statements)
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“…The classical hypothesis that cell death is required for palatogenesis has been proposed based on the observations as follows: (1) some MEE cells develop ultrastructural changes that are characteristic to dead cells prior to and/or during palatal fusion (Farbman,1968;Shapiro and Sweney, 1969;Chaudhry and Shah, 1973); (2) MEE cells cease DNA synthesis prior to the fusion of palatal shelves (Hudson and Shapiro, 1973;Pratt and Martin, 1975;Greene and Pratt, 1976); and (3) lysosomal enzyme levels in MEE cells increase prior to or during palatal fusion (Hayward, 1969;Smiley, 1970;Pratt and Greene, 1976). Furthermore, several morphological studies detected degenerated cells in the midline epithelial seam and among disappearing midline epithelial cells (Farbman, 1968;Hayward, 1969;Mato et al, 1972;Pratt and Hassel, 1975).…”
Section: Discussionmentioning
confidence: 99%
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“…The classical hypothesis that cell death is required for palatogenesis has been proposed based on the observations as follows: (1) some MEE cells develop ultrastructural changes that are characteristic to dead cells prior to and/or during palatal fusion (Farbman,1968;Shapiro and Sweney, 1969;Chaudhry and Shah, 1973); (2) MEE cells cease DNA synthesis prior to the fusion of palatal shelves (Hudson and Shapiro, 1973;Pratt and Martin, 1975;Greene and Pratt, 1976); and (3) lysosomal enzyme levels in MEE cells increase prior to or during palatal fusion (Hayward, 1969;Smiley, 1970;Pratt and Greene, 1976). Furthermore, several morphological studies detected degenerated cells in the midline epithelial seam and among disappearing midline epithelial cells (Farbman, 1968;Hayward, 1969;Mato et al, 1972;Pratt and Hassel, 1975).…”
Section: Discussionmentioning
confidence: 99%
“…It has been shown that MEE cells cease incorporating 3 Hlabeled thymidine approximately 24 hours prior to initial contact of the opposing palatal shelves (Hudson and Shapiro, 1973;Pratt and Martin, 1975;Greene and Pratt, 1976). This phenomenon has been interpreted as a preparation of MEE cells to die.…”
Section: Discussionmentioning
confidence: 99%
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“…Programmed cell death of the MEE following the initial adherence of the palatal shelves was originally hypothesized (Shapiro and Sweney, 1969;Hudson and Shapiro, 1973;Pratt and Martin, 1975;Pratt and Greene, 1976;Pratt et al, 1984). The other two fates for the MEE were more recently proposed.…”
Section: Fate Of the Medial Edge Epitheliummentioning
confidence: 99%
“…Since no cell proliferation occurs in the medial edge epithelium (HUDSON and SHAPIRO, 1973), the palatal growth may result in the thinning of the seam and formation of the nasal and oral epithelial triangles and of the epithelial pearls. This may explain the reason why TUNEL-positive nuclei of MEE cells rarely appeared in the seam, as has been suggested by CARETTE and FERGUSON (1992), who have further reported that no degenerative cell appears in the triangles.…”
Section: Apoptosis Of Mee Cells During the Palatal Formationmentioning
confidence: 99%