“…Serum calcium declined, whereas blood urea nitrogen, serum creatinine, and serum glutamic pyruvic transaminase were highly elevated after application of TSST-1. At necropsy, most rabbits had mottled, congested livers, dark red cervical, thoracic, and mesenteric lymph nodes, dark, congested thymuses and spleens, and mottled, congested lungs [9]. The histological changes seen in tissues of rabbits infected with TSST-1-negative S. aureus, engineered by phage-transfer to express the TSST-1 gene and thus, produce the toxin, were remarkably similar to those described in tissues from human patients with TSS [11,13].…”