A Rabbit Lung Model for Testing Reaction to Inhaled Dental Restorative Particles

Goldberg, Norma Boone; Goldberg, Allen Fred; Gergans, Gregory A.; Loga, S; Taschini, Pierangelo; Molnar, Zelma

doi:10.1378/chest.101.3.829

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…With resin-based composites, there are some concerns that, in addition to the leaching of (co) monomers, micro-and nano-sized filler particles may be worn, swallowed or inhaled and then be accumulated in the tissues. These accumulations may be linked to diseases of the liver, kidney, lung and intestine [29][30][31] . The particle size of the dust grains created during grinding and polishing of resin composite fillings with diamond burs and rubber instrument is -depending on the material-in the micrometer and submicrometer range (between <100 nm and >15 µm), as shown in an in vivo study, where 75% of the particles were smaller than 2.5 µm ( Fig.…”

Section: Clinical Importance Of Wear Of Teeth and Restorative Materialsmentioning

confidence: 99%

Wear of dental materials: Clinical significance and laboratory wear simulation methods —A review

Heintze

Reichl²,

Hickel

2019

Dent. Mater. J.

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This review focusses on tribological aspects of teeth during function, the clinical significance of wear, wear of natural teeth and restorative materials and laboratory methods to simulate wear of restorative materials. Ceramic, metal alloy and amalgam show low material wear, whereas resin-based materials demonstrate substantial wear in the long term. The clinical wear shows a high variability with the patient factor accounts for about 50% of the variability. Wear as such seldomly compromises the function of the stomatognath system or individual teeth and is in most cases an esthetic problem. Particles that are ingested due to attrition and abrasion wear may pose a health risk to the patient, especially those from composite resin materials. However, systematic clinical studies on that issue are not available. For laboratory research many wear simulation devices and methods have been developed but only few are validated and have a moderate correlation with clinical wear.

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Section: Clinical Importance Of Wear Of Teeth and Restorative Materialsmentioning

confidence: 99%

Wear of dental materials: Clinical significance and laboratory wear simulation methods —A review

Heintze

Reichl²,

Hickel

2019

Dent. Mater. J.

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“…2‐Hydroxyethylmethacrylate (HEMA) and triethleneglycoldimethacrylate (TEGDMA) are important composite components occurring in amounts of about 20 to 60% in dental fillings 9. Both compounds are released from fillings by abrasion or elution and are also known to be inhalated or incorporated by ingestion 10–12. Moreover, recent results suggest that exhalation is an important pathway of elimination of these compounds 13.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of ingredients of various dental materials and related compounds in L2‐ and A549 cells

Walther

Liebl

et al. 2002

J. Biomed. Mater. Res.

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Various ingredients of dental materials and related compounds were tested for cytotoxicity in two alveolar epithelial cell lines (L2 and A549 cells). Release of lactate dehydrogenase (LDH) from cells was measured after incubation with the test substances for time intervals up to 48 h and expressed as percentage of total LDH content of lysed cells. Furthermore, the glutathione content of cells was determined in the nonmalignant L2 cells. Additionally, cell viability was assessed by microscopic examination. The highest cytotoxicity was observed with mercury compounds (methylmercuric chloride and mercury dichloride) in the range of 5-20 micromol/l. The composite components 2-hydroxyethylmethacrylate (HEMA) and triethleneglycoldimethacrylate (TEGDMA) showed time- and concentration-dependent effects of cytotoxicity at high concentrations (about 1-5 mmol/l). A time dependence for GSH decrease was mainly found for the composite components up to 12 h of cellular exposure. L2 cells were more sensitive to both mercury and composite compounds than A549 cells. Gold compounds (sodiumaurothiomalate and gold particles < 1.5 microm) did not produce any sign of toxic reactions. A time-dependent increased toxicity in pulmonary cell lines was found for the composite components HEMA and TEGDMA, but not for mercury and gold compounds.

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Resin-Based Composites

Schmalz

Biocompatibility of Dental Materials

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A Rabbit Lung Model for Testing Reaction to Inhaled Dental Restorative Particles

Cited by 8 publications

References 13 publications

Wear of dental materials: Clinical significance and laboratory wear simulation methods —A review

Wear of dental materials: Clinical significance and laboratory wear simulation methods —A review

Cytotoxicity of ingredients of various dental materials and related compounds in L2‐ and A549 cells

Resin-Based Composites

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