A quantitative study of the progress of myelination in the rat central nervous system, using the immunohistochemical method for proteolipid protein

Hamano, Kenzo; Takeya, Toshiki; Iwasaki, Naoko; Nakayama, Junko; Ohto, Tatsuyuki; Okada, Yusuke

doi:10.1016/s0165-3806(98)00063-7

Cited by 59 publications

(45 citation statements)

References 22 publications

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“…25,37 Indeed, the improvement in the diffusion indices as evidenced by reduction in the differences in FA, trace, and Ќ between injury and control ECs suggests a component of "recovery," though this was not complete, even at the final young adult time point. Furthermore, our results showed that this recovery process mainly occurred between day 1 and day 7 post-HI injury, which corresponds to the timing of rapid increase in myelination during the normal maturation process 34,38 and is consistent with a study by Liu et al, 25 who demonstrated recovery of myelin within the first 3 weeks after mild HI injury. Potentially, our results may reflect the therapeutic window for recovery of myelination that is important in optimizing the timing of treatment in mild hypoxia-ischemia.…”

Section: Discussionsupporting

confidence: 92%

Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging

Wang

Wu²,

Cai³

et al. 2009

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 92%

Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging

Wang

Wu²,

Cai³

et al. 2009

AJNR Am J Neuroradiol

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“…nation seen in the CNS throughout (Hamano et al, 1998;Salami et al, 2003). Interestingly, this was the one property we measured that had not reached a stable phenotype by P17.…”

Section: Discussionmentioning

confidence: 83%

“…Interestingly, this was the one property we measured that had not reached a stable phenotype by P17. Indeed, myelination of the internal capsule [which pallidonigral and striatonigral fibers pass through in rodents (Totterdell et al, 1984;Gustafson et al, 1989)] does not reach maturity until P42 (Hamano et al, 1998). By measuring the straight line distance between the stimulating electrode and the SNr, we calculated that the conduction velocity of medium spiny axons was 0.7 m/s, in excellent agreement Ryan et al (1986), whereas pallidonigral axons conducted at 2.3 m/s.…”

Section: Discussionmentioning

confidence: 85%

Differential Short-Term Plasticity at Convergent Inhibitory Synapses to the Substantia Nigra Pars Reticulata

Connelly¹,

Schulz²,

Lees³

et al. 2010

J. Neurosci.

129

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Inhibitory projections from the striatum and globus pallidus converge onto GABAergic projection neurons of the substantia nigra pars reticulata (SNr). Based on existing structural and functional evidence, these pathways are likely to differentially regulate the firing of SNr neurons. We sought to investigate the functional differences in inhibitory striatonigral and pallidonigral traffic using whole-cell voltage clamp in brain slices with these pathways preserved. We found that striatonigral IPSCs exhibited a high degree of paired-pulse facilitation. We tracked this facilitation over development and found the facilitation as the animal aged, but stabilized by postnatal day 17 (P17), with a paired pulse ratio of 2. We also found that the recovery from facilitation accelerated over development, again, reaching a stable phenotype by P17. In contrast, pallidonigral synapses show paired-pulse depression, and this depression could be solely explained by presynaptic changes. The mean paired-pulse ratio of 0.67 did not change over development, but the recovery from depression slowed over development. Pallidonigral IPSCs were significantly faster than striatonigral IPSCs when measured at the soma. Finally, under current clamp, prolonged bursts of striatal IPSPs were able to consistently silence the pacemaker activity of nigral neurons, whereas pallidal inputs depressed, allowing nigral neurons to reinstate firing. These findings highlight the importance of differential dynamics of neurotransmitter release in regulating the circuit behavior of the basal ganglia.

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“…Extending incubation times beyond 6 weeks appeared to have no consistent effect on the degree of labeling although this parameter can be important for visualizing projections (Lukas et al, 1998;Sparks et al, 2000). Perhaps myelination is more advanced for projections to the contralateral IC than for ipsilaterally projecting axons (e.g., sequential myelination of corpus callosum, Looney and Elberger, 1986; differential myelination of spinal tracts, Hamano et al, 1998) and, thus, interferes with DiI confusion or detection. The earlier birth dates of contralaterally projecting LSO cells in comparison with ipsilaterally projecting cells (Kudo et al, 1996) suggest that contralateral axon development could precede that for ipsilateral projections.…”

Section: Labeling and Histologymentioning

confidence: 96%

Development of banded afferent compartments in the inferior colliculus before onset of hearing in ferrets

et al. 2007

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Axonal projections from the lateral superior olivary nuclei (LSO), as well as from the dorsal cochlear nucleus (DCN) and dorsal nucleus of the lateral lemniscus (DNLL), converge in frequency-ordered layers in the central nucleus of the inferior colliculus (IC) where they distribute among different synaptic compartments. A carbocyanine dye, DiI, was used as a tracer to study the postnatal development of axonal projections in the ferret IC. The results indicated that projections from all three nuclei are present at birth, but are not segregated into bands. During the postnatal week between approximately postnatal days 4 and 12 (P4-P12), axons from LSO proliferate in IC, become more branched, and segregate into a series of bands composed of densely packed fibers and endings. LSO projections in these afferent bands course parallel to IC layers and are separated by intervening regions with few endings. A modest fit of a sine curve (R 2 >0.15) to the pattern of spacing of LSO projections in IC indicated that regularly spaced bands are forming by P7. Similarly, banded patterns of DCN and DNLL projections to IC have developed by the end of the first postnatal week. Thus, well before hearing onset in ferret (P28-30), three different afferent projections have segregated into banded compartments along layers in the central nucleus of the ferret IC. Possible mechanisms in circuit development are discussed.

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A quantitative study of the progress of myelination in the rat central nervous system, using the immunohistochemical method for proteolipid protein

Cited by 59 publications

References 22 publications

Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging

Mild Hypoxic-Ischemic Injury in the Neonatal Rat Brain: Longitudinal Evaluation of White Matter Using Diffusion Tensor MR Imaging

Differential Short-Term Plasticity at Convergent Inhibitory Synapses to the Substantia Nigra Pars Reticulata

Development of banded afferent compartments in the inferior colliculus before onset of hearing in ferrets

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