1981
DOI: 10.1002/path.1711350405
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A quantitative study of lamina densa alterations in hamster cheek pouch carcinogenesis

Abstract: Lesions produced by topical application of 0.5 per cent. DMBA to the hamster cheek pouch epithelium were classified as hyperplasia, dysplasia and carcinoma groups using strict histological criteria. Untreated epithelium served as a control. Tissue samples from five animals in each group were processed for electron microscopy and electron micrographs from the epithelial-connective tissue junction were obtained from 5 blocks per animal. The micrographs were subjected to stereological intersection counting to det… Show more

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Cited by 21 publications
(10 citation statements)
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References 42 publications
(43 reference statements)
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“…Disturbances in the integrity of the basal lamina have been observed in many pathological and experimental conditions (Pearson and Spargo, 1961;Pearson, 1962Pearson, ,1967Caulfield and Wilgram, 1962;Kubacek, 1962;Wilgram, 1967;Johnson and Fry, 1967;Frithiof, 1969;Vracko, 1972Vracko, , 1978Vracko, , 1979Nikai et al, 1971;Ericksson and Frithiof, 1972;Vracko and Benditt, 1972;Sugimoto et al, 1973;Takarada et al, 1974;Jao et al, 1978;Ingber et al, 1981;White and Gohari, 1981;Otsubo and Kameyama, 1982;Yasuzumi et al, 1983). The disturbances include irregularities in thickness, reduplication (multilayer formation), detachment from the basal cells (i.e., increased width of lamina lucida), and fragmentation.…”
Section: Discussionmentioning
confidence: 99%
“…Disturbances in the integrity of the basal lamina have been observed in many pathological and experimental conditions (Pearson and Spargo, 1961;Pearson, 1962Pearson, ,1967Caulfield and Wilgram, 1962;Kubacek, 1962;Wilgram, 1967;Johnson and Fry, 1967;Frithiof, 1969;Vracko, 1972Vracko, , 1978Vracko, , 1979Nikai et al, 1971;Ericksson and Frithiof, 1972;Vracko and Benditt, 1972;Sugimoto et al, 1973;Takarada et al, 1974;Jao et al, 1978;Ingber et al, 1981;White and Gohari, 1981;Otsubo and Kameyama, 1982;Yasuzumi et al, 1983). The disturbances include irregularities in thickness, reduplication (multilayer formation), detachment from the basal cells (i.e., increased width of lamina lucida), and fragmentation.…”
Section: Discussionmentioning
confidence: 99%
“…The lamina densa opposite the hemidesmosomes often appeared to be of increased electron density and thickness. During carcinogenesis (Figs 2-6) a progressive loss of lamina densa and the extrusion of pseudopodia occurred at the epithelial-connective tissue junction (as in Tarin, 1967;Woods & Smith, 1969; White & Gohari, 1981b;Smith, 1980). This was accompanied by an apparent decrease in frequency of hemidesmosomes, which became apparent in the later stages of carcinogenesis.…”
Section: Qualitative Observationsmentioning
confidence: 93%
“…Basal eells were present in eontaet with the basal lamina eomplex. fn those eases where basal lamina was absent (White & Gohari 1981b) the cells in direct eontaet with connective tissue were eonsidered as basal eells. Granular cells contained keratohyaline granules.…”
Section: Materials Andmentioning
confidence: 99%