A Quantitative Structure-Property Relationship for Predicting Drug Solubility in PEG 400/Water Cosolvent Systems

Rytting, Erik; Lentz, Kimberley A.; Chen, Xue Qing; Qian, Feng; Venkatesh, Srini

doi:10.1023/b:pham.0000016237.06815.7a

Cited by 45 publications

(34 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The aqueous solubility of a poorly-water soluble drug was shown to be significantly enhanced by up to five orders of magnitude at 80 wt.% of PEG (MW 400) [27,28]. The PTX solubility in PEG dendrimers was even higher than that in PEG (MW 400) solution at the same weight concentration [29,30], probably due to the high local density and conformation arrangement inside the PEG dendrimer.…”

Section: Discussionmentioning

confidence: 99%

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Kang¹,

Robinson²,

Park³

et al. 2007

Journal of Controlled Release

View full text Add to dashboard Cite

Mechanisms underlying the release of paclitaxel (PTX) from poly(ethylene glycol)/poly(lactic-coglycolic acid) (PEG/PLGA) blends were investigated by coherent anti-Stokes Raman scattering (CARS) microscopy. PLGA, PEG, and PTX were selectively imaged by using the resonant CARS signal from the CH 3 , CH 2 , and aromatic CH stretch vibrations, respectively. Phase segregation was observed in PLGA films containing 10 to 40 wt.% PEG in the absence of PTX loading. The PEG phase existed in the form of crystalline fibers in the (8:2, weight ratio) and (7:3) PLGA/PEG films. CARS observation indicated that PTX preferentially partitioned into the PEG domains in the (9:1) and (8:2) PLGA/PTX films, but exhibited a uniform mixing with both PLGA and PEG in the (7:3) PLGA/PEG film. The solid dispersion of PTX into PEG domains was attributed to a strong interaction between PTX and PEG, supported by the disappearance of PEG crystallization in the PTX-loaded PLGA/PEG film evidenced through X-ray diffraction analysis. PTX release was induced by exposing the film to an aqueous solution and monitored in real time by CARS and two-photon fluorescence microscopy. Fast dissolution of both PEG and PTX was observed at the film surface. Upon infiltration of water into the film, the PEG domains rearranged into ring structures enriched by both PTX and PEG. The CARS data provided a visual evidence explaining the accelerated burst release followed by more sustained release of PTX from the PLGA/PEG films as measured by HPLC.

show abstract

Section: Discussionmentioning

confidence: 99%

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Kang¹,

Robinson²,

Park³

et al. 2007

Journal of Controlled Release

View full text Add to dashboard Cite

show abstract

“…Table A1 lists the molecules studied, along with the mp and ABSOLV descriptors. [8,68] a Compound names: underlined = calorimetric data; italic = excluded data; double asterisk = "n=2, different labs" data (see text).…”

Section: Glossary Of Termsmentioning

confidence: 99%

Solubility Temperature Dependence Predicted from 2D Structure

Avdeef

2015

ADMET DMPK

View full text Add to dashboard Cite

show abstract

“… Rytting et al [24] free-base and -acid (no salts used) shake-flask S w : solubility of 122 molecules were gathered, all measured in one laboratory, with S 0 calculated by pDISOL-X.…”

Section: Datamentioning

confidence: 99%

“…The pH of the drug-saturated solution can vary from 6-10, depending on how much CO 2 is dissolved in water and how insoluble the basic compound is. For example, Rytting et al [24] reported log S w = -4.87 (molarity) for terfenadine dissolved in water. If CO 2 content in solution were ignored, the calculated log S 0 = -5.7 and pH sat = 9.2.…”

Section: Limitations Of Intrinsic Solubility S 0 Determined From Amentioning

confidence: 99%

“…In the two curated compilations, the pH of saturated solutions had not been reported for most of the ionizable compounds. In addition, smaller databases of crystalline drug-like molecules have been published (Analytical Profiles of Drug Substances [22], McFarland et al [23]; Rytting et al [24]; Bergström et al [25]; Faller and Ertl [18]; Llinàs et al [26]; Hopfinger et al [27]). These smaller databases consist largely of intrinsic solubility values, S 0 -i.e., the solubility of the neutral species.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs

Avdeef

2015

ADMET DMPK

View full text Add to dashboard Cite

show abstract

A Quantitative Structure-Property Relationship for Predicting Drug Solubility in PEG 400/Water Cosolvent Systems

Cited by 45 publications

References 16 publications

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy

Solubility Temperature Dependence Predicted from 2D Structure

Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs

Contact Info

Product

Resources

About