A quantitative radiological assessment of outcomes of autogenous bone graft combined with platelet-rich plasma in the alveolar cleft

Lee, C.; Nishihara, Kazuhide; Okawachi, Takako; Iwashita, Youichirou; Majima, Hideyuki J.; Nakamura, Norifumi

doi:10.1016/j.ijom.2008.11.019

Cited by 59 publications

(53 citation statements)

References 14 publications

(12 reference statements)

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“…However, even if PRP does not provide a benefit for secondary bone grafting, it does not prevent bone formation [13]. Furthermore, PRP promotes easier handling of PCBM due to the fibrin in PRP working as a "glue" to bind the We showed in the present case successful treatment with alveolar bone grafting and simultaneous auto-tooth transplantation.…”

Section: Discussionmentioning

confidence: 63%

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Secondary Bone Grafting With Simultaneous Auto-Tooth Transplantation to the Alveolar Cleft

Miura

Yoshida

Asahina

2015

Journal of Oral and Maxillofacial Surgery

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One of the most important purposes of secondary bone grafting of the alveolar cleft is to stabilize the maxillary alveolar arch with completion of the dental arch. We report here a case of secondary bone grafting with simultaneous auto-tooth transplantation to the alveolar cleft, using 5 particulate cancellous bone and marrow (PCBM) combined with platelet-rich plasma (PRP), which contains many growth factors. The patient was born with a bilateral cleft lip and left buccal-localized cleft alveolus. We performed a bone grafting to the cleft using PCBM with PRP, and a transplantation of the supernumerary tooth under general anesthesia 10 at 11 years and 10 months of age. The postoperative course was uneventful and without any complications. Orthodontic treatment was nearly complete 10 months after the operation. The transplanted tooth was stable, and normal gingival contour was attained over the 2-year follow-up period. The case was successful in achieving a stable occlusal condition in a short period 15 of time. We suggest the secondary bone grafting with simultaneous 3 auto-tooth transplantation as an option for alveolar cleft treatment.

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Section: Discussionmentioning

confidence: 63%

“…5 Despite these advantages of PCBM, resorption of newly formed bone may occur, and the height and width of the regenerated residual ridge may decrease unless functional stress is applied to the transplanted site [13,14].…”

Section: Discussionmentioning

confidence: 99%

Secondary Bone Grafting With Simultaneous Auto-Tooth Transplantation to the Alveolar Cleft

Miura

Yoshida

Asahina

2015

Journal of Oral and Maxillofacial Surgery

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“…Occlusal radiographs at approximately 3 and 6-12 months post-SBG were acquired to observe the grafted bone, the volume of which has been reported to decrease significantly until 3 months post-SBG. 24 Therefore, we evaluated ABG scores at an early phase of the post-SBG period by using the earliest of occlusal radiographs acquired 3-12 months post-SBG. Orthodontic treatment after SBG might help close the gap in the maxillary dental arch, and the ''functional stress'' imposed by orthodontic treatment might influence the volume of grafted bone and prevent its resorption.…”

Section: Discussionmentioning

confidence: 99%

“…Orthodontic treatment after SBG might help close the gap in the maxillary dental arch, and the ''functional stress'' imposed by orthodontic treatment might influence the volume of grafted bone and prevent its resorption. 24,25 For these reasons, orthodontists often begin treatment for movement of cleft-adjacent teeth in the direction of the grafted bone after an average duration of 3 months post-SBG. 7,8 In the present study, of the 18 patients with no/moderate EARR and 12 patients with severe EARR, 12 (66.7%) and 6 (50.0%) patients, respectively, began orthodontic treatment within 3 months post-SBG to prevent resorption of the grafted bone (P ¼ .458; Fisher's exact test).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate—Part 2: Relationship between root resorption, horizontal tooth movement, and quantity of grafted autogenous bone

Maeda‐Iino

Furukawa

Kwon

et al. 2017

The Angle Orthodontist

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Objective: To evaluate the relationship between external apical root resorption (EARR) of the maxillary central incisors (U1), horizontal orthodontic tooth movement, and quantity of grafted bone in subjects with unilateral cleft lip and palate (UCLP) over an average duration of 8 years. Materials and Methods: Thirty subjects with UCLP were evaluated for EARR of U1 after edgewise treatment (T2). The teeth were classified as having no EARR, moderate EARR (combined into ''no/ moderate'' EARR), or severe EARR. Frontal cephalometric radiographs acquired at eruption of U1 (T0), less than 6 months before secondary alveolar bone grafting (T1), and T2 were evaluated to determine the horizontal inclination (U1-axis angle) and distance of the root apex from the median line (U1-root-VL distance). On the cleft side, the quantities of grafted bone at less than 12 months postsecondary bone grafting and at T2 were evaluated using the alveolar bone graft (ABG) scale. Results: Cleft-adjacent teeth exhibited more severe EARR than did teeth on the noncleft side. The cleft side exhibited greater changes in U1-axis angle and U1-root-VL distance between T0 and T2 than did the noncleft side. On the cleft side, the ABG score at T2 in the severe EARR group was significantly lower than that in the no/moderate EARR group. These measurements were correlated with EARR grade. Conclusions: Cleft-adjacent U1 exhibited more severe EARR than did the U1 on the noncleft side, which might be associated with orthodontic treatment-induced changes in horizontal inclination and root apex movement. On the cleft side, severity of EARR may be correlated with the success of

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“…[185][186][187][188][189] PRP is an autologous and cost-effective source, that can be easily obtained and contains multiple growth factors that could serve for MSC expansion. 190 formation in artificially-induced alveolar defects when combined with bioactive glass foams.…”

Section: Enhancing Cell-scaffold Combinationmentioning

confidence: 99%

Stem cell regenerative therapy in alveolar cleft reconstruction

Gładysz¹,

Hozyasz²

2015

Archives of Oral Biology

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A quantitative radiological assessment of outcomes of autogenous bone graft combined with platelet-rich plasma in the alveolar cleft

Cited by 59 publications

References 14 publications

Secondary Bone Grafting With Simultaneous Auto-Tooth Transplantation to the Alveolar Cleft

Secondary Bone Grafting With Simultaneous Auto-Tooth Transplantation to the Alveolar Cleft

Evaluation of maxillary central incisors on the noncleft and cleft sides in patients with unilateral cleft lip and palate—Part 2: Relationship between root resorption, horizontal tooth movement, and quantity of grafted autogenous bone

Stem cell regenerative therapy in alveolar cleft reconstruction

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