A quantitative MRI study of the corpus callosum in children and adolescents

A Unified Statistical Approach to Deformation-Based Morphometry

“…Therefore, we observe a highly focused region of brain tissue growth in the isthmus and splenium of the corpus callosum. Pujol et al (1993), Giedd et al (1996bGiedd et al ( , 1999, and Thompson et al (2000) reported similar results of growth pattern at the corpus callosum. The growth at the corpus callosum seems relatively small when compared to the global peaks observed predominantly in somatosensory and motor cortex (the largest red cluster in Fig.…”

Corpus Callosum Morphology and Microstructure Assessed Using Structural MR Imaging and Diffusion Tensor Imaging: Initial Findings in Adults with Neurofibromatosis Type 1

“…Moreover, the CC continues to grow throughout childhood and early adulthood, [23][24][25] but the growth is unequal, with some regions growing at different rates than others. 26,27 One possible explanation for the increased size of the CC in children with NF-1 is a delay and/or reduction in apoptosis, 3,6 which would produce greater numbers of commissural fibers. Other possible causes include larger axons due to excessive myelination, increased extracellular fluid, myelinopathy associated with vacuolation, 20,28 or a combination of those factors.…”

Brain Commissural Anomalies

“…It is reported that the adult morphology of corpus callosum is achieved by 16.4 weeks (115 days) (Loser & Alvord, 1968) so that it is clearly identified. The studies have shown that the linear association are between the corpus callosum length, thickness and width, with age before ( Achiron & Achiron, 2001) and after birth (children and young people aged 4 to 18 years) ( Giedd et al, 1996;Pujol et al, 1993 ). The length of the corpus callosum increases a 10-fold during gestation and rapid growth of thickness increases during the period between 16 and 20 weeks' gestation.…”

“…From ventral to dorsal, the lamina reunions (Fig. 1) gives rise to the area praecommissuralis (origin of the anterior commissure), to the primordium hippocampi (10 intra uterine weeks,fornix), and to the massa commissuralis (10 intra uterine weeks., corpus callosum) .The plate acts as a passive bed for axonal passage and provides a preformed glial pathway to guide decussating growth cones of commissural axons (Silver et al, 1982).In the human embryo the genu of corpus callosum begins to develop around 8th week after conception (Giedd et al, 1996) and inter-hemispheric crossing fibres begin to transverse the massa commissuralis in this region at 11 to 12 weeks post-conceptional age (Griffiths et al, 2009) and progress caudally, forming the body (corpus) and the splenium (Rakic & Yakovlev, 1968), so that at 18 weeks' gestation the genu and body are detected cleanly; but the splenium is thin and not fully developed (Malinger & Zakut ,1993).The last part of the corpus callosum that to form at the weeks 18-20 post-conceptional ages is the rostrum (Griffiths et al, 2009;Destrieux et al, 1998). It is reported that the adult morphology of corpus callosum is achieved by 16.4 weeks (115 days) (Loser & Alvord, 1968) so that it is clearly identified.…”