A quantitative method using near infrared imaging spectroscopy for determination of surface composition of tablet dosage forms: an example of spirolactone tablets
Abstract:Neste trabalho, a espectroscopia de imagens no infravermelho próximo (NIR) foi empregada no estudo da distribuição do princípio ativo (API) espironolactona e seus excipientes em comprimidos. As análises foram realizadas utilizando resolução espacial de 50 µm, analisando 16 mm 2 de cada comprimido padrão. Modelos de mínimos quadrados parciais por intervalo (iPLS) foram utilizados para quantificação dos excipientes e API em cada pixel afim de obter mapas de concentração para cada composto. Foram obtidos erros de… Show more
“…Additionally, compositional mapping can be undertaken [11]. Therefore, the goal of this study is to demonstrate the use of LIBS for PCB characterization by combining hyperspectral images [12][13][14] and score maps obtained from principal component analysis (PCA). The use of hyperspectral images permits the simultaneous observation of the chemical distribution of multiple elements in a given sample.…”
“…Additionally, compositional mapping can be undertaken [11]. Therefore, the goal of this study is to demonstrate the use of LIBS for PCB characterization by combining hyperspectral images [12][13][14] and score maps obtained from principal component analysis (PCA). The use of hyperspectral images permits the simultaneous observation of the chemical distribution of multiple elements in a given sample.…”
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