A Quantitative Magnetic Resonance Imaging Study of Changes in Brain Morphology From Infancy to Late Adulthood

Pfefferbaum, Adolf; Mathalon, Daniel H.; Sullivan, Edith V.; Rawles, Jody M.; Zipursky, Robert B.; Lim, Kelvin O.

doi:10.1001/archneur.1994.00540210046012

Cited by 1,234 publications

(846 citation statements)

References 38 publications

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“…Here, it is important to note that the 'ages of peak' in WM investigations are variable and, in some particular cases, the decline of FA scores in aged subjects was not significant (McLaughlin et al, 2007). Moreover, some classical studies (Benes et al, 1994;Pfefferbaum et al, 1994) reported constant WM volumes or even signs of myelination until the seventh decade of life. Yet, we still claim that some additional processes or confounding factors must be investigated in the future.…”

Section: Discussionmentioning

confidence: 99%

Brain oscillatory complexity across the life span

Fernández

Zuluaga

Abásolo

et al. 2012

Clinical Neurophysiology

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Objective: Considering the increasing use of complexity estimates in neuropsychiatric populations, a normative study is critical to define the 'normal' behaviour of brain oscillatory complexity across the life span. Method:This study examines changes in resting-state magnetoencephalogram (MEG) complexity -quantified with the Lempel-Ziv complexity (LZC) algorithm -due to age and gender in a large sample of 222 (100 males/122 females) healthy participants with ages ranging from 7 to 84 years.Results: A significant quadratic (curvilinear) relationship (p < 0.05) between age and complexity was found, with LZC maxima being reached by the sixth decade of life.Once that peak was crossed, complexity values slowly decreased until late senescence.Females exhibited higher LZC values than males, with significant differences in the anterior, central and posterior regions (p < 0.05). Conclusions:These results suggest that the evolution of brain oscillatory complexity across the life span might be considered a new illustration of a 'normal' physiological rhythm.Significance: Previous and forthcoming clinical studies using complexity estimates might be interpreted from a more complete and dynamical perspective. Pathologies not 3 only cause an 'abnormal' increase or decrease of complexity values but they actually 'break' the 'normal' pattern of oscillatory complexity evolution as a function of age.Keywords: Life Span, Ageing, Complexity, Brain Development, White Matter Development Highlights 1. A significant quadratic (curvilinear) relationship between age and oscillatory complexity exists, with complexity maxima reached by the sixth decade of life.2. As in previous studies, females exhibit higher complexity values than males, at least in some brain regions.3. The evolution of oscillatory complexity across the life span is interpreted as a physiological rhythm which is altered by several brain pathologies.

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Section: Discussionmentioning

confidence: 99%

Brain oscillatory complexity across the life span

Fernández

Zuluaga

Abásolo

et al. 2012

Clinical Neurophysiology

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“…Second, the age range of the subjects is limited and inferences on age-related changes in CSF volumes must be derived primarily from the literature. However, the literature consistently indicate that CSF volumes of the lateral ventricles and frontal lobe CSF increase with age (Coffey et al 1992;Jernigan et al 1990;Matsumae et al 1996;Pfefferbaum et al 1994;Wahlund et al 1990). Third, the statistical analyses did not correct for multiple comparisons; however, the analyses were conducted with clear hypotheses in mind.…”

Section: Discussionmentioning

confidence: 99%

“…Regardless, this data supports the possibility that decreasing subcortical and cortical brain volumes (whether accelerated by drug use or not) may be associated with a reduced ability to experience cocaine-induced euphoria. Since the CSF volumes related to these brain regions are known to increase with age (Coffey et al 1992;Jernigan et al 1990;Matsumae et al 1996;Pfefferbaum et al 1994;Wahlund et al 1990;Bartzokis, unpublished data) it is possible that with age, the ability to achieve cocaine-induced euphoria diminishes. This may result in age-related reductions in drug use.…”

Section: Discussionmentioning

confidence: 99%

“…Rates are highest among the young (17% for ages 18-29), considerably less in middle age (4% for ages 30-59), and virtually non-existent in those over 60 (Miller 1991). While such figures may represent the "wisdom" commonly associated with aging, they may also reflect age-related brain changes (Bartzokis et al 2000;Coffey et al 1992;Gottfries et al 1983;Jernigan et al 1990;Lepage et al 1985;Lim et al 1992;Matsumae et al 1996;Pfefferbaum et al 1994;Raz et al 1998;Sullivan et al 1995;Wahlund et al 1990;Wang et al 1996), which alter the balance between the addicting versus the aversive effects of cocaine by diminishing the euphoric experience of drug intoxication. Consequently, the tendency to develop a dependence syndrome decreases and the capacity to discontinue use increases (Miller 1991;Cook and Harrell 1987;Facy et al 1991;Bartzokis et al 1999b,c).…”

Section: Discussionmentioning

confidence: 99%

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Increased CSF Volumes Are Associated with Diminished Subjective Responses to Cocaine Infusion

Bartzokis

Beckson

et al. 2000

Neuropsychopharmacology

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We evaluated the hypothesis that ventricular and cortical CSF volume increases are associated with reductions in the magnitude of euphoric effects produced by intravenous IV cocaine infusion in cocaine dependent (CD) individuals. Eleven CD patients participating in a cocaine-infusion study and eleven control subjects underwent magnetic resonance imaging (MRI). Two CSF regions of interest (lateral ventricles and frontal cortex CSF) and two comparison regions (third ventricle and posterior cortex CSF) were measured. Self-reported ratings of the intensity of euphoric response ("high") were obtained from the CD subjects at 3, 10, and 30 minutes after IV administration of cocaine. A significant negative correlation was observed between the volume of the lateral ventricles and subjective ratings of the "high" experienced at 3 minutes, but not at 10 The relationship between brain variables and subjective effects of cocaine has not been extensively studied. Morgan et al. (1993), using non-contrast computerized tomography (CT), examined the association between ventricular brain ratio (VBR) and intensity of response to the effects of 40 mg of intravenous cocaine. They obtained subjective ratings of drug effect every minute for 30 minutes after the cocaine injection and observed a significant negative correlation (r ϭ Ϫ .53, p ϭ .02) between VBR and the average rating of drug response over the first 10 minute interval but no relationship over the last two 10 minute intervals (r ϭ Ϫ .22 and r ϭ (Morgan et al. 1993). This suggested that subjects with larger ventricles had reduced sensitivity to cocaine's immediate euphoric effects.As part of a recent study investigating the possible attenuating effects of selegiline on cocaine-induced euphoria and brain metabolism (Bartzokis et al. 1999a), non-treatment seeking "crack" cocaine smokers were evaluated with magnetic resonance imaging (MRI) of the brain in order to identify patients with enlarged ventricles who may be less responsive to IV cocaine's euphoric effects. The total volume of the lateral ventricles was measured in order to evaluate the magnitude of the negative association between this volume measure and the experience of euphoria ("high") associated with cocaine infusion. The volume of the third ventricle was also measured in order to assess whether this structure/function association was specific to the lateral ventricles or a phenomenon associated with generalized ventriculomegaly.In addition, the volume of the supracortical cerebrospinal fluid (CSF) in the frontal region of the cerebral cortex was measured in order to indirectly assess whether reduced frontal cortex gray matter observed in the polysubstance dependent (Liu et al. 1998) and alcohol dependent (Pfefferbaum et al. 1998) populations is also associated with a diminished intensity of cocaine infusion-induced euphoria. As with the ventricular volumes, we hypothesized that the volume of CSF in this cortical region will also correlate negatively to the cocaine infusion-associated experience of euphoria...

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“…Neuroimaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) have substantiated the findings from postmortem studies (see [34], for a review) that nonpathological aging is associated with considerable morphological brain changes. Widening of the ventricular and sulcal liquor spaces is clearly evident in elderly persons [2,6,8,21,22,27], and studies that directly measured brain volume have found age-related reductions in total and gray (but not white) matter volumes [8,21,30,31]. This atrophy seems to occur particularly in the frontal and temporal lobes [8,31], and also in subcortical regions [20].…”

Section: Introductionmentioning

confidence: 99%

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

Tisserand

Visser

Boxtel

et al. 2000

Neurobiology of Aging

117

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The present study investigated the range of age-related changes in brain morphology and the relation with performance on memory and other cognitive tests in a healthy population. A group of 61 subjects (21 to 81 years old, mean ϭ 55.7), free from cognitive and medical deficits, underwent MRI scanning and neuropsychological assessment encompassing memory and other cognitive tests. Volumetry of the hippocampus, parahippocampal gyrus, mamillary bodies, third ventricle, and total brain matter was performed. The results indicate that in healthy individuals increases in ventricular volume and volume decreases in total brain matter, hippocampus and parahippocampal gyrus, but not mamillary bodies, are clearly apparent with increasing age. However, no relation could be established between the brain volumes and test performance when controlling for the effects of age. To conclude, variations in total and limbic brain volumes do not seem predictive for cognitive performance independent of age.

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A Quantitative Magnetic Resonance Imaging Study of Changes in Brain Morphology From Infancy to Late Adulthood

Cited by 1,234 publications

References 38 publications

Brain oscillatory complexity across the life span

Brain oscillatory complexity across the life span

Increased CSF Volumes Are Associated with Diminished Subjective Responses to Cocaine Infusion

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

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