A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24–36 weeks of gestation

Karaçay, Ö.; Sepici-Dinçel, Aylin; Karçaaltıncaba, Deniz; Şahin, Duygu; Yalvaç, Serdar; Akyol, Mesut; Kandemir, Ömer; Altan, Nilgün

doi:10.1016/j.diabres.2010.04.015

Cited by 123 publications

(89 citation statements)

References 27 publications

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“…Although increased oxidative stress is already accepted to be implicated in preeclampsia, either as a pathogenetic mechanism or as a consequence, the controversy about the possible roles of antioxidant status and enzyme levels remains [28]. A number of studies reported decreased TAS levels as a reduction in antioxidant defense mechanisms in preeclampsia [22,27,29]. These studies are contradictory to our results since we found significantly increased levels of TAS in severely preeclamptic patients.…”

Section: Discussioncontrasting

confidence: 57%

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Öztaş

Özler²,

Tokmak³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to determine maternal serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON) and arylesterase levels in severe preeclamptic pregnants and also to investigate whether these parameters are implicated in the occurence of perinatal morbidity or not. Material and methods:A case-control study was carried out including 60 pregnant women (30 with severe preeclampsia and 30 healthy controls). The optimal cut off points of oxidative stress markers for the diagnosis of severe preeclampsia and for the prediction of adverse perinatal outcomes were evaluated by receiver operating characteristic (ROC) analyses. Multivariate logistic regression analysis was used to determine if a relationship between adverse perinatal outcomes and serum oxidative stress markers was present or not.Results: TAS (OR = 37.486, 95% CI 3.535-397.519, p = 0.003), TOS (OR = 15.588, 95% CI 2.135-113.818, p = 0.007) and arylesterase (OR = 31.356, 95% CI 2.284-430.548, p = 0.01) were found to be diagnostic for preeclampsia. Statistically significant positive correlation of adverse perinatal outcomes with serum TAS, PON and arylesterase levels were determined. Besides, a significant negative correlation was found between serum TAS levels and gestational week (r = -0.342, p = 0.007) and also between serum PON levels and birthweight (r = -0.262, p = 0.043). Conclusions:Increased maternal serum TAS, TOS and arylesterase levels are significantly associated with the presence of severe preeclampsia. Furthermore, elevated maternal serum TAS, PON and arylesterase levels are significantly and positively correlated with adverse perinatal outcomes. We suggest that in preeclampsia increased oxidative status may cause adverse perinatal outcomes and antioxidants may be increased in order to protect the fetus against oxidative damage.

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Section: Discussioncontrasting

confidence: 57%

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Öztaş

Özler²,

Tokmak³

et al. 2016

Ginekol Pol

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“…Glycemic levels in GDM were correlated with concentrations of lipid peroxides and increased protein oxidation [14]. Increased biomarkers of oxygen radical damage have been identified in GDM, such as myeloperoxidase and malonaldehyde levels [15,16]. These preliminary results demonstrated that the increase in the levels of BChE, γ-GT, Cys-C, and pre-albumin may be indicative of oxidative stress in GDM.…”

Section: Discussionmentioning

confidence: 53%

Surrogate Markers of the Kidney and Liver in the Assessment of Gestational Diabetes Mellitus and Fetal Outcome

Liu

et al. 2015

JCDR

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“…1) [9,51,62]. Moreover, the positive correlation between POOHs and glycated haemoglobin A 1c (HbA 1c ) has been found in GDM women [62].…”

Section: Biomarkers Of Oxidative Damagementioning

confidence: 95%

“…Numerous studies have revealed increased MDA and TBARS levels in maternal and cord blood as well as in placenta from pregnancies complicated by GDM (Tab. 1) [44][45][46][47][48][49][50][51][52][53][54][55][56][57]. Additionally, MDA level has been found to positively correlate with blood glucose concentration [40].…”

Section: Biomarkers Of Oxidative Damagementioning

confidence: 99%

Stres oksydacyjny indukowany hiperglikemią w cukrzycy ciążowej (GDM)

Turek

Woźniak

Cypryk

et al. 2015

Clinical Diabetology

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A quantitative evaluation of total antioxidant status and oxidative stress markers in preeclampsia and gestational diabetic patients in 24–36 weeks of gestation

Cited by 123 publications

References 27 publications

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Surrogate Markers of the Kidney and Liver in the Assessment of Gestational Diabetes Mellitus and Fetal Outcome

Stres oksydacyjny indukowany hiperglikemią w cukrzycy ciążowej (GDM)

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