A Quantitative Evaluation of the Posterior Segment of the Eye Using Spectral-Domain Optical Coherence Tomography in Carotid Artery Stenosis: a Pilot Study

Sayın, Nihat; Kara, Necip; Uzun, Fatih; Aktürk, İbrahim Faruk

doi:10.3928/23258160-20150213-20

Cited by 50 publications

(51 citation statements)

References 34 publications

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“…e blood supply to the choroid arises from the ophthalmic branch of the internal carotid artery (ICA) via the short ciliary arteries [17,29]. Stenosis of the ICA results in the reduction of arterial pressure distal to the stenosis, including brain and ocular circulation.…”

Section: Discussionmentioning

confidence: 99%

Impact of Carotid Endarterectomy on Choroidal Thickness and Volume in Enhanced Depth Optical Coherence Tomography Imaging

Krytkowska

Masiuk

Kawa

et al. 2020

Journal of Ophthalmology

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Purpose. Carotid endarterectomy (CEA) is considered an effective therapeutic method for improving ocular circulation. The choroid is a predominantly vascular tissue; thus, systemic and local vascular alterations may influence its morphology and function. The aim of the current study was to analyse changes in choroidal thickness and volume in patients with significant internal carotid artery stenosis (ICAS) before and after unilateral CEA. Methods. The 42 eyes of the 21 asymptomatic patients included in the study were divided into two groups: those ipsilateral (EIE) and those contralateral (ECE) to CEA. All participants underwent a complete ophthalmologic examination, including enhanced depth imaging-optical coherence tomography (EDI-OCT). A comparative analysis of subfoveal thickness (CT) and choroidal volume (CV) measured in nine Early Treatment of Diabetic Retinopathy Study (ETDRS) subfields at baseline, on the 2nd day after CEA, and in the 3rd month after CEA was performed. Results. In the EIE and ECE groups, no significant differences in either CT or CV values before and on the 2nd day after the CEA were observed. In the EIE group, a significant increase in CT and CV in the 3rd month after CEA compared to baseline was noted in the specific ETDRS region. Changes in CT and CV after surgery were positively correlated with the participants’ physical activity status and diastolic blood pressure and negatively correlated with the participants’ age and smoking status. Additionally, the analysis of changes in CV after CEA showed a positive correlation between the EIE and ECE groups. Conclusions. CT and CV fluctuations in the central and perifoveal areas visualized with EDI-OCT enabled the observation of the processes of tissue adaptation to variable blood flow conditions.

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Section: Discussionmentioning

confidence: 99%

Impact of Carotid Endarterectomy on Choroidal Thickness and Volume in Enhanced Depth Optical Coherence Tomography Imaging

Krytkowska

Masiuk

Kawa

et al. 2020

Journal of Ophthalmology

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show abstract

“…Although hypertensive retinopathy has been associated with increased CTh [11], correlations between CTh and systemic hypertension in healthy retinas have been inconsistent, with one study showing significantly thinner CTh compared with healthy controls [17] and another showing no significant association [18]. Similarly, internal carotid artery stenosis has been variably associated with CTh, with one study showing a positive correlation between extent of stenosis and CTh [19] and another showing an inverse relationship [20]. A study by Agladioglu et al noted an inverse relationship between internal carotid artery diameter and CTh; however, this finding was in healthy patients without stenosis [35].…”

Section: Discussionmentioning

confidence: 99%

“…Uncomplicated hypercholesterolemia without other vascular disease has been associated with choroidal thickening [12], whereas cigarette smoking [13,14], ocular ischemic syndrome [15], chronic heart failure [16], and systemic essential hypertension [17,18] have been linked to a thinner choroid. Carotid artery stenosis [19,20] and diabetes without diabetic retinopathy [21,22] have shown contradictory associations with CTh. In this study, we compared macular CTh in 34 patients with CAD to macular CTh in 28 healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness in patients with coronary artery disease

et al. 2017

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PurposeTo evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls.DesignCross-sectional.MethodsSetting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure. Twenty-eight age-matched controls had no self-reported history of CAD or diabetes. Patients with high myopia, dense cataracts, and retinal disease were excluded. Observation procedures: Enhanced depth imaging optical coherence tomography and questionnaire regarding medical and ocular history. Main outcome measures: Subfoveal CTh and CTh 2000 μm superior, inferior, nasal, and temporal to the fovea in the left eye, measured by 2 readers.ResultsCTh was significantly lower in patients with CAD compared to controls at the subfoveal location (252 vs. 303 μm, P = 0.002) and at all 4 cardinal macular locations. The mean difference in CTh between the 2 groups ranged from 46 to 75 μm and was greatest in the inferior location. Within the CAD group, CTh was significantly lower temporally (P = 0.007) and nasally (P<0.001) than subfoveally, consistent with the pattern observed in controls. On multivariate analysis, CAD was negatively associated with subfoveal CTh (P = 0.006) after controlling for diabetes, hypertension, and hypercholesterolemia.Conclusions and relevancePatients with CAD have a thinner macular choroid than controls, with preservation of the normal spatial CTh pattern. Decreased CTh might predispose patients with CAD to high-risk phenotypes of age-related macular degeneration such as reticular pseudodrusen and could serve as a potential biomarker of disease in CAD.

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“…21 Choroidal hypoperfusion as a consequence of ICA obstruction resulted in multiple occlusions of the choriocapillaris and attenuated the choroidal vessels. 22 More importantly, CEA procedures on the carotid arteries have resulted in the recovery of choroidal thickness in all patients with hemodynamically significant ICA stenosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of carotid endarterectomy on retinal function in 'asymptomatic' patients with hemodynamically significant carotid artery stenosis

Machalińska¹,

Kowalska-Budek²,

Kawa³

et al. 2017

Polish Archives of Internal Medicine

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A Quantitative Evaluation of the Posterior Segment of the Eye Using Spectral-Domain Optical Coherence Tomography in Carotid Artery Stenosis: a Pilot Study

Abstract: The results suggest that CT decreases in patients with ICA stenosis compared with age-matched healthy individuals, whereas the RNFL, macular, and GCC thicknesses are comparable.

Cited by 50 publications

References 34 publications

Impact of Carotid Endarterectomy on Choroidal Thickness and Volume in Enhanced Depth Optical Coherence Tomography Imaging

Impact of Carotid Endarterectomy on Choroidal Thickness and Volume in Enhanced Depth Optical Coherence Tomography Imaging

Choroidal thickness in patients with coronary artery disease

Effect of carotid endarterectomy on retinal function in 'asymptomatic' patients with hemodynamically significant carotid artery stenosis

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