A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

Li, Xinxin; Wu, Wei; Zhou, Hao; Deng, Junjie; Zhao, Mengya; Qian, Tianwei; Yan, Chao; Xu, Xun; Yu, Shizhu

doi:10.18240/ijo.2018.11.09

Cited by 34 publications

(29 citation statements)

References 45 publications

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“…Nevertheless, the different evaluation approaches used in these studies and in the present study (especially the thresholding methods and the evaluated regions) make it almost impossible to conduct comparisons among various studies, although these aforementioned studies reported that these devices showed good or even excellent repeatability. Additionally, a few previous studies had demonstrated that the quantitative measurements were not directly interchangeable among different OCT-A systems [2–4]. However, only few studies compared their repeatability on the same cohort.…”

Section: Discussionmentioning

confidence: 99%

“…With OCT-A quantification becoming increasingly common, there is a pressing need to understand whether OCT-A systems can provide reliable and stable quantitative results and to determine which OCT-A system has better repeatability when using a specific scan pattern in clinical practice. Several studies have evaluated the reproducibility of various OCT-A systems; the results of these studies indicate that the outcomes of these instruments are generally uninterchangeable [2–4]. Therefore, the repeatability of one OCT-A system should be taken into consideration when that OCT-A system is used.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems

Yang

Yuan

Wang

et al. 2019

Journal of Ophthalmology

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The aim of this study was to compare the repeatability of optical coherence tomography angiography (OCT-A) measurements of macular vessel density using four OCT-A systems, including Heidelberg Spectralis HRA, Optovue RTVue XR, Zeiss Cirrus HD-OCT 5000, and Topcon DRI OCT Triton. A cross-sectional design was used for this study. The vascular density and vascular length density of the superficial and deep retinal capillary plexuses were imaged with OCT-A using 3 mm and 6 mm scan patterns and were calculated using ImageJ. Comparisons of intraclass correlation coefficients (ICC) were conducted. We found that the OCT-A systems had various levels of repeatability. Zeiss had better repeatability for vessel density than the other systems (overall ICC = 0.936). Optovue had better repeatability for vessel length density when the 6 mm scan pattern was used (ICC = 0.680 and 0.700 for retinal superficial and deep capillary plexus, respectively). We concluded that repeatability varied when different scan patterns of various OCT-A systems were used for imaging the superficial retinal and deep capillary plexuses. Results should be seen as valid only for a given method. The repeatability of various OCT-A systems should be considered in clinical practice and in clinical trials that use OCT-A metrics as outcome measures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems

Yang

Yuan

Wang

et al. 2019

Journal of Ophthalmology

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“…The axial resolution is 5 µm, the lateral resolution is 15 µm and the imaging depth is 2–3 mm. 32 Examination of NVDs was performed using 3 x 3 and 4.5 x 4.5 mm volume protocols in Angio Disc mode. Evaluation of NVEs was performed in Angio Retina mode using 3 x 3 mm, 6 x 6 mm or 8 x 8 mm scans, with the larger scans used for the larger complexes.…”

Section: Methodsmentioning

confidence: 99%

“…The resolution is identical to the Avanti RTVue XR OCT and the imaging depth is 2 mm. 32 NVDs were imaged using 3 x 3 mm scan areas and NVEs using 3 x 3 mm, 6 x 6 mm or 8 x 8 mm scans. Scans with a quality of at least 6/10 were included.…”

Section: Methodsmentioning

confidence: 99%

<p>Optical Coherence Tomography Angiography Features of Neovascularization in Proliferative Diabetic Retinopathy</p>

Vaz-Pereira¹,

Silva²,

Freund³

et al. 2020

OPTH

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To describe features of neovascularization in proliferative diabetic retinopathy (PDR) using optical coherence tomography angiography (OCTA). Methods: A retrospective case series was performed in 23 eyes from 21 patients who underwent OCTA of neovascular complexes (NVCs) due to PDR. Eyes were imaged with the DRI Triton swept-source OCTA, Avanti RTVue XR or Cirrus HD-OCT 5000 as part of routine clinical examination. Segmentation was adjusted to include vasculature between the vitreous cavity and the internal limiting membrane (ILM). The presence of NVCs was confirmed by clinical examination and multimodal imaging such as color or red-free fundus photography, fluorescein angiography, multicolor imaging or near-infrared reflectance. Results: Thirty-five NVCs were imaged, of which, 34% were neovascularization of the disc (NVD) and 66% were neovascularization elsewhere (NVE). On structural OCT B-scans, NVE appeared as medium to highly reflective tissue that breached the ILM, while NVD showed highly reflective tissue protruding from the disc in a sea fan configuration. Flow signal was seen on OCTA in all cases of NVE and in 67% of NVD lesions. Areas with minimal or absent retinal flow signal identified retinal nonperfusion areas and were found adjacent to 87% of NVE. Intraretinal microvascular abnormalities (IRMAs) were noted next to 70% of NVE. Absent flow signal was seen in 4 NVD cases showing posterior shadowing and were considered inactive. Conclusion: OCTA appears useful for imaging NVCs, IRMAs, and retinal nonperfusion areas in eyes with diabetic retinopathy. This imaging modality enables noninvasive screening and monitoring of PDR and can obviate the need for additional testing in certain clinical settings.

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“…Several different approaches were used to analyze the decorrelation between repeated B-scans, using various components of the complex OCT signal [70][71][72], with distinct advantages and disadvantages in each of these approaches. Different vendors have also used different methods for calculating and displaying the OCT angiogram and thus comparability between different machines is not possible [73]. (E) The image of the deep plexus was segmented from the IPL to the outer plexiform layer (OPL).…”

Section: Principle Of Optical Coherence Tomography Angiographymentioning

confidence: 99%

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

Chua

Sim

Tan

et al. 2020

JCM

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Diabetic retinopathy (DR) is a common complication of diabetes mellitus that disrupts the retinal microvasculature and is a leading cause of vision loss globally. Recently, optical coherence tomography angiography (OCTA) has been developed to image the retinal microvasculature, by generating 3-dimensional images based on the motion contrast of circulating blood cells. OCTA offers numerous benefits over traditional fluorescein angiography in visualizing the retinal vasculature in that it is non-invasive and safer; while its depth-resolved ability makes it possible to visualize the finer capillaries of the retinal capillary plexuses and choriocapillaris. High-quality OCTA images have also enabled the visualization of features associated with DR, including microaneurysms and neovascularization and the quantification of alterations in retinal capillary and choriocapillaris, thereby suggesting a promising role for OCTA as an objective technology for accurate DR classification. Of interest is the potential of OCTA to examine the effect of DR on individual retinal layers, and to detect DR even before it is clinically detectable on fundus examination. We will focus the review on the clinical applicability of OCTA derived quantitative metrics that appear to be clinically relevant to the diagnosis, classification, and management of patients with diabetes or DR. Future studies with longitudinal design of multiethnic multicenter populations, as well as the inclusion of pertinent systemic information that may affect vascular changes, will improve our understanding on the benefit of OCTA biomarkers in the detection and progression of DR.

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A quantitative comparison of five optical coherence tomography angiography systems in clinical performance

Cited by 34 publications

References 45 publications

Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems

Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems

<p>Optical Coherence Tomography Angiography Features of Neovascularization in Proliferative Diabetic Retinopathy</p>

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

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