A quantitative comparison of a bone remodeling model with dual-energy X-ray absorptiometry and analysis of the inter-individual biological variability of femoral neck T-score

Effects of Ovariectomy and Anatomical Position on the Compact Bone as Seen in Three Month Summer Ovine Model

“…The adequate conjugation of diagnostic imaging tools, DEXA, along with computational numeric simulations may increase the knowledge on bone remodeling and on bone strength [16]. Consistent validation methodologies are mandatory to obtain valid results, and furthermore the inclusion of patient-specific information, to express the interindividual geometric and biological variability is also valuable in the computational model [16]. In one such study the methodology proposed represented a partial validation of the bone remodeling model in terms of bone mineral content (BMC) for a specific region, namely the femoral neck [16].…”

“…Consistent validation methodologies are mandatory to obtain valid results, and furthermore the inclusion of patient-specific information, to express the interindividual geometric and biological variability is also valuable in the computational model [16]. In one such study the methodology proposed represented a partial validation of the bone remodeling model in terms of bone mineral content (BMC) for a specific region, namely the femoral neck [16]. In their study DEXA exams were performed on the femur of Caucasian women of post-menopausal age and a descriptive statistical study of the patients was conducted using their BMD values, age, height, weight, and body mass index (BMI) [16].…”

“…In one such study the methodology proposed represented a partial validation of the bone remodeling model in terms of bone mineral content (BMC) for a specific region, namely the femoral neck [16]. In their study DEXA exams were performed on the femur of Caucasian women of post-menopausal age and a descriptive statistical study of the patients was conducted using their BMD values, age, height, weight, and body mass index (BMI) [16]. A computational model was applied to a three-dimensional finite element model of the proximal femur for 25 values of k, which can be understood as the cost supplied by the human body for bone remodeling depending on age, hormonal status, and disease status [16].…”

“…In their study DEXA exams were performed on the femur of Caucasian women of post-menopausal age and a descriptive statistical study of the patients was conducted using their BMD values, age, height, weight, and body mass index (BMI) [16]. A computational model was applied to a three-dimensional finite element model of the proximal femur for 25 values of k, which can be understood as the cost supplied by the human body for bone remodeling depending on age, hormonal status, and disease status [16]. Both methods were then compared and it was found that there is a set of k values that are able to closely predict the mean formal neck BMC [16].…”

“…A computational model was applied to a three-dimensional finite element model of the proximal femur for 25 values of k, which can be understood as the cost supplied by the human body for bone remodeling depending on age, hormonal status, and disease status [16]. Both methods were then compared and it was found that there is a set of k values that are able to closely predict the mean formal neck BMC [16].…”