A quantitative application of the <i>J</i>‐based configuration analysis method to a flexible small molecule

Sharman, Gary J.

doi:10.1002/mrc.1971

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Determination Of Solution Conformations Of the Uncomplexed L1

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2008

2016

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Cited by 6 publications

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“…NMR is the experimental tool of choice to explore conformational properties, especially of flexible small molecules in solution [55][56][57] . Interpretation of NMRderived structural parameters in combination with molecular modeling usually offers a view of the accessible conformations to ligands.…”

Section: Determination Of Solution Conformations Of the Uncomplexed Lmentioning

confidence: 99%

The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR

Sánchez-Pedregal

Griesinger

2008

Topics in Current Chemistry

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Tubulin is a fascinating molecule that forms the cytoskeleton of the cells and plays an important role in cell division and trafficking of molecules. It polymerizes and depolymerizes in order to fulfill this biological function. This function can be modulated by small molecules that interfere with the polymerization or the depolymerization. In this article, the structural basis of this behavior is reviewed with special attention to the contribution of NMR spectroscopy. Complex structures of small molecules that bind to tubulin and microtubules will be discussed. Many of them have been determined using NMR spectroscopy, which proves to be an important method in tubulin research.

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Section: Determination Of Solution Conformations Of the Uncomplexed Lmentioning

confidence: 99%