Peptic ulcer disease is the most common ulcer of an area of the gastro-intestinal tract. The aim of this study is to utilize soft computing techniques to manage uncertainty and imprecision in measurements related to the size, shape of the abnormality. For this, we designed a fuzzy inference system (FIS) which emulates the process of human experts in detection and analysis of the peptic ulcer. The proposed approach models the vagueness and uncertainty associated to measurements of small objects in low resolution images In this study, for the first time, we applied soft computing technique based upon fuzzy inference system (FIS) for assessment of the