A quantitative analysis of marker compounds in single herb extracts by the standard of KHP

Abstract

Objectives : Since single extract powders was released at 1987, the insurance fee has not been changed, but the price of raw material has been increasing. According to this, Pharmaceutical company couldn't invest on quality of the product, so, the quality of single extracts went down and lost the consumer's trust. We checked the contents of marker ingredients in single extract thereby to recover the reliability of insurance-covered herbal preparations. Methods : we bought total twelve products of eight different single extracts of two main pharmaceutical companies among total 65 kinds of single extract powder stipulated in KHP (The Korean Herbal Pharmacopoeia) monograph Ⅲ at Jan. 2013. Assays of selected single extract powders are performed by KHP regulation. And we surveyed price fluctuation of relevant herb raw materials from 2005 to 2012. Results : Among twelve products, eight single extract powders were suitable by the KHP regulation. But four products didn't reach the content amount of KHP. Marker contents in the single extracts product of Pueraria Root, Licorice, Peony root and Scutellaria Root of A company were 70%, 1%, 23.7% and 75.1%, respectively. Conclusions : We can acertain whether there's a quality problem in the insurance-covered single extract powders. But, A company is no longer producing these improper single extract powders. As a medicine, single extract powders needs to be strictly quality controlled by the company, and regularly monitored by the KFDA.

Antiviral Effect of Hyunggaeyungyo-tang on A549 Cells Infected with Human Coronavirus

“…Insured herbal extracts are widely prescribed due to the low cost to patients, but differ from packaged herbal medications because they contain extracts of a single herb [14]. For this reason, Uninsured Herbal Extracts, which are most similar to packed herbal medicines, are widely prescribed despite the cost burden of patients.…”

Antiviral Effect of Hyunggaeyungyo-Tang on A549 Cells Infected with Human Coronavirus

“…According to a study by Son et al [ 13 ], 58.19% of Korean medicine doctors use uninsured herbal extracts. Insured herbal extracts are widely prescribed due to the low cost to patients but differ from packaged herbal medications because they contain extracts of a single herb [ 14 ]. For this reason, uninsured herbal extracts, which are most similar to packed herbal medicines, are widely prescribed despite the cost burden of patients.…”

A Study about Quality Control of Herb Medicine Extract Granules About DanggwiSayeuggaosuyusaenggangtang(DSGOST)

“…Herb medicine is made based on the principle of Korean medicine and composed of various single herb medicine. Demand for the herb medicine is increasing with the prolonged life expectancy and chronic degenerative diseases 2,6) . Herb medicine is known to be experientally effective & safe from side effects 1) .…”

“…In addition, More than 70% of Gemarn local doctors prescribe natural substance. In Japan and China, Use of Complex herb medicine is increasing as well 6) .…”

“…Lately, preference of granuled herb medicine is incresing than boiled herb medicine on account of taking convenience, transportability, storage safety and so on 2) . However, some complex herb extract granules received revocation of permission because it got poor laboratory results about quality from KFDA inspection in 2014 6) . In conclusion, Complex herb medicine may have possibility to various quality depending on manufacturing company.…”