A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia

Vandermosten, Maaike; Boets, Bart; Wouters, Jan; Ghesquière, Pol

doi:10.1016/j.neubiorev.2012.04.002

Cited by 298 publications

(359 citation statements)

References 152 publications

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“…18,46,47 The arcuate fasciculus (AF), which is part of the superior longitudinal fasciculus (SLF), may subserve the dorsal phonological route, while the inferior frontooccipital fasciculus (IFOF) and the inferior longitudinal fasciculus (ILF) may subserve the ventral orthographic route. However, DTI fiber tracking studies for reading are relatively sparse, and most prior studies have made assumptions regarding the specific white matter tracts that may be involved.…”

mentioning

confidence: 99%

Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study

Motomura¹,

Fujii²,

Maesawa³

et al. 2014

JNS

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T he ability to read and write is associated with a widely distributed cortical or subcortical neuronetwork. Brain lesions in cases of acquired alexia or agraphia are distributed throughout the dominant network of the frontal to occipital lobes. These lesions are thought to be related to various subcortical fibers.40 Previous reports of alexia and agraphia have localized the disorders to a restricted area, the left inferior parietal lobule and, more specifically, the angular and supramarginal gyri. 1,2,9,10,33,40 These findings imply that lesions resulting in alexia with agraphia may be related to damage in common subcortical pathways necessary for reading and writing, including cerebral white matter tracts.Recent noninvasive diagnostic techniques such as functional MRI (fMRI) and diffusion tensor imaging (DTI) have enabled characterization of the neuroanatomical distribution of various functions within the brain.Regarding reading and alexia, previous fMRI studies have revealed that reading is performed by a dominanthemisphere network of inferior frontal and temporoparietal areas that constitute a dorsal phonological route and occipitotemporal cortical regions that form a ventral orthographic reading route. 18,46,47 The arcuate fasciculus (AF), which is part of the superior longitudinal fasciculus (SLF), may subserve the dorsal phonological route, while the inferior frontooccipital fasciculus (IFOF) and the inferior longitudinal fasciculus (ILF) may subserve the ventral orthographic route. However, DTI fiber tracking studies for reading are relatively sparse, and most prior studies have made assumptions regarding the specific white matter tracts that may be involved. 29,46,50 In terms of functional and structural aspects, the writing process has been associated with the lateral posterior parietal cortex in the dominant hemisphere. 8,16 Within the lateral posterior parietal cortex, lesions inAssociation of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study Alexia and agraphia are disorders common to the left inferior parietal lobule, including the angular and supramarginal gyri. However, it is still unclear how these cortical regions interact with other cortical sites and what the most important white matter tracts are in relation to reading and writing processes.Here, the authors present the case of a patient who underwent an awake craniotomy for a left inferior parietal lobule glioma using direct cortical and subcortical electrostimulation. The use of subcortical stimulation allowed identification of the specific white matter tracts associated with reading and writing. These tracts were found as portions of the dorsal inferior frontooccipital fasciculus (IFOF) fibers in the deep parietal lobe that are responsible for connecting the frontal lobe to the superior parietal lobule. These findings are consistent with previous diffusion tensor imaging tractography and functional MRI studies, which suggest that the IFOF may play a r...

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mentioning

confidence: 99%

Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study

Motomura¹,

Fujii²,

Maesawa³

et al. 2014

JNS

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“…While substantial support for the early involvement of dorsal tracts, including the AF and SLF is present in literature [12,[26][27][28], mixed evidence is presented for ventral tracts, including UF, ILF, and IFO [28][29][30][31]. Additionally, most of these studies have focused on a restricted age range (i.e., [5][6][7][8][9][10][11][12][13][14]), and left-hemispheric white-matter tracts.…”

Section: Discussionmentioning

confidence: 99%

“…stage, children are beginning to use their newly learned skills to read longer texts and accordingly, the white-matter tracts are also undergoing major transformations. This is supported by the fact that the children start gaining experience in reading words and are starting to automatically recognize the whole word representations for faster reading [28,29,51]. This type of mapping involves both orthographic and semantic processing.…”

Section: Ventral Tracts Reading Acquisitionmentioning

confidence: 99%

The Relationship between White Matter and Reading Acquisition, Refinement and Maintenance

Cheema

Cummine

Study³

2018

Dev Neurosci

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Reading requires efficient communication between brain regions that are situated all over the cortex. These brain areas are structurally connected by white-matter pathways that develop over the period of reading acquisition. Here, we conducted a cross-sectional study to assess the relationship between white-matter tracts and reading performance across the lifespan. Methods: Behavioral (reading performance) and neuroimaging (diffusion tensor imaging [DTI]) data were collected from participants aged 3–21 years as a part of the multi-site project called the pediatric imaging neurocognition genetics study. DTI measures (fractional anisotropy [FA], mean diffusivity, radial diffusivity and axial diffusivity) of bilateral dorsal tracts (arcuate fasciculus, superior longitudinal fasciculus, and posterior superior longitudinal fasciculus) and ventral tracts (uncinate fasciculus, inferior fronto-occipital fasciculus, and inferior longitudinal fasciculus) were extracted. Reading performance was calculated as the number of items correctly read (words for older children and letters in the case of young children). Correlational and regression analyses were conducted between the DTI measures and reading scores. Results: During the early stages of reading acquisition (ages 3–6), the dorsal tracts were positively related to reading performance (as FA goes up, reading performance goes up). For ages 6–10, the dorsal tracts remain positively associated with reading performance and a relationship between ventral tracts and reading performance emerges. From the age of 10 onwards, the dorsal tracts no longer correlate with reading performance, and a brain-behavior relationship in the right ventral tracts begins to shift, whereby higher FA is associated with lower reading performance. In addition to the involvement of left hemispheric tracts, this study revealed the initial engagement of right hemispheric tracts during the early stages of reading acquisition. Conclusion: We discuss these different associations of white-matter tracts with reading during development in the context of the biological processes model of myelination and pruning.

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“…In contrast, posterior regions of the corpus callosum, such as the splenium display greater FA values in adults and children with DD than typically developing controls [49,[58][59][60]. In typical development, the splenium consists of small densely packed axons; thus, splenium enlargement suggests a greater number of axons and greater interhemispheric connectivity [56].…”

Section: The Role Of the Corpus Callosum In Reading And Developmentalmentioning

confidence: 99%

Predicting Developmental Dyslexia: A Brief Review of Genetics, Language and the Brain

Figuccio¹

2017

J Child Dev Disord

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Learning to read is an essential life skill, yet many children struggle and may even fail to learn to read. Developmental dyslexia (DD) is a specific learning disorder characterized by deficits in reading and reading-related tasks. Even though early intervention is crucial for successful remediation, many children do not receive a diagnosis until second grade or later. Research has shown high heritability of DD. Additionally, a link has been established between early language abilities and the development of reading skills. Moreover, individuals with DD display differences in neural structures implicated in reading even prior to learning to read compared to their typically developing peers. The aim of this review is to identify genetic, language, and brain predictors of reading.

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A qualitative and quantitative review of diffusion tensor imaging studies in reading and dyslexia

Cited by 298 publications

References 152 publications

Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study

Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study

The Relationship between White Matter and Reading Acquisition, Refinement and Maintenance

Predicting Developmental Dyslexia: A Brief Review of Genetics, Language and the Brain

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