A QSPR study of drug release from an arabinoxylan using ab initio optimization and neural networks

Akbar, Jamshed; Iqbal, Mohammad S.; Chaudhary, Muhammad Taimoor; Yasin, Tallat; Massey, Shazma

doi:10.1016/j.carbpol.2012.02.016

Cited by 17 publications

(6 citation statements)

References 33 publications

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“…The release of TZN from buccal film was retarded efficiently by ARX and it has allowed 87.86% of the drug to release in 8 hrs. It was in-line with the previous studies that ARX has the ability to provide sustained effect[ 14 , 15 ]. PEG 400, which was used as plasticizer in IR layer, is an effective co solvent and can enhance the solubility as well as dissolution rate of the poorly water soluble drugs like MLX.…”

Section: Resultssupporting

confidence: 90%

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation

2018

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The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate release (IR) layer-forming polymer. Prepared films were subjected to in-vitro drug release, surface morphology, mechanical strength, compatibility of the ingredients, drug contents, ex-vivo mucoadhesion strength and drug permeation. Crossover study design was applied to study the in-vivo pharmacokinetics by using albino rabbits. Various pharmacokinetic parameters including AUC, Cmax, tmax and t1/2 of both drugs loaded in films were compared with standard solution/dispersion administered to the rabbits at the dose of 1mg/kg. The results unveiled instant release and permeation of MLX from IR layer, while good controlled release and permeation characteristics of TZN from SR films over 8 h. films were of uniform thickness with smooth surface and satisfactory mechanical strength. Mucoadhesion strength was sufficient to provide suitable contact time with mucosal membrane. The pharmacokinetic study exhibited prompt absorption of MLX with better AUC 0-t (6655.64 ng/ml*h vs 6538.99 ng/ml*h) and Cmax (436.98 ng/ml vs 411.33 ng/ml) from oral dispersion. Similarly buccal films has shown enhanced half-life (9.91hr vs 2.51 hr), AUC 0-t (1043.4 ng/ml*h vs 149.1 ng/ml*h) and Cmax (91.92 ng/ml vs 42.29 ng/ml) from oral solution. A statistical investigation disclosed a significantly improved pharmacokinetics of TZN and MLX after their absorption across buccal route following administration of buccal film (p<0.05). ARX proved expedient and bilayer buccal films as a drug delivery system ascertained the dual effect of providing instant release of one active agent and persistent release of another one with improved pharmacokinetics.

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Section: Resultssupporting

confidence: 90%

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation

2018

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“…Psyllium has shown potential to be exploited as safe and effective drug carrier in pharmaceutical industry. Psyllium and its chemically modified derivatives have been explored for modification of water absorbing, gelling, and release properties [ 6 ]. In pharmaceutical applications psyllium and its modifications have earlier been explored for preparing sustained release matrix and colon specific drug delivery [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Thiol Modification of Psyllium Husk Mucilage and Evaluation of Its Mucoadhesive Applications

Bhatia

Ahuja

2013

The Scientific World Journal

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Thiol functionalization of psyllium was carried out to enhance its mucoadhesive potential. Thiolation of psyllium was achieved by esterification with thioglycolic acid. Thiolation was observed to change the surface morphology of psyllium from fibrous to granular and result in a slight increase in the crystallinity and swelling. Thiolated psyllium was found to contain 3.282 m moles of thiol groups/g of the polymer. Mucoadhesive applications of thiolated psylium were explored by formulating gels using metronidazole as the model drug. On comparative evaluation thiolated psyllium gels showed 3-fold higher mucoadhesive strength than the psyllium gels as determined by modified physical balance using chicken buccal pouch. The results of in vitro release study revealed that thiolated psyllium gels provided a prolonged release of metronidazole. Further, the psyllium and thiolated psyllium gels were found to release the drug following first-order kinetics by combination of polymer relaxation and diffusion through the matrix.

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“…They are the second most abundant biomass on earth. Arabinoxylan (AX) from psyllium (Plantago ovata) seed husk, one of the most studied hemicelluloses, presents a great promise for drug delivery formulations [25][26][27][28]. Over past two decades, this polymer has been extensively characterized with regard to its structure and composition [26,[29][30][31][32].…”

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confidence: 99%

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

et al. 2020

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Hemicelluloses are biopolymers with versatile properties for biomedical applications. Herein, hemicellulose (arabinoxylan)-based antibacterial film dressings were prepared and characterized. Arabinoxylan was isolated from psyllium husk. Blank and gentamicin-loaded films were prepared by the solvent cast method using glycerol as the plasticizer. The appropriate composition of the films was obtained by varying the amounts of arabinoxylan, glycerol, and gentamicin. The films were found to be transparent, smooth, bubble-free, flexible, and easily peelable with 2% to 3% arabinoxylan. They had uniform thickness and swelled up to 60% of their initial size. The mechanical properties and water vapor transmission rate through the films were found to be suitable for wound-dressing application. Fourier transform infrared spectroscopy (FTIR) analysis confirmed drug–film compatibility. In an in vitro release study, more than 85% of the gentamicin was released from the films in 12 h. The antibacterial activities of the gentamicin-loaded films were found to be close to the standard gentamicin solution. The films were found to be cytocompatible in cell viability assay. These results suggested that hemicellulose-based films are promising materials for the dressing of infected wounds.

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A QSPR study of drug release from an arabinoxylan using ab initio optimization and neural networks

Cited by 17 publications

References 33 publications

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation

Thiol Modification of Psyllium Husk Mucilage and Evaluation of Its Mucoadhesive Applications

Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application

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