A pyrazole-containing selenium compound modulates neuroendocrine, oxidative stress, and behavioral responses to acute restraint stress in mice

Selenium and Its Compounds in the Treatment of Anxiety and Related Disorders: A Scoping Review of Translational and Clinical Research

“…Sixteen of the papers included in this review belonged to this category [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. Methodological details and results for each of these studies are summarized in Table 1.…”

“…Methodological details and results for each of these studies are summarized in Table 1. Fourteen studies examined the effects of selenium or selenium compounds on animal models of anxiety [43][44][45][46][47][48][49][50][51][52][53][54][55][56]. Of these studies, the majority (n = 10) used organic seleniumcontaining compounds as interventions, while two used elemental selenium and two used sodium selenite.…”

“…In seven studies, anxiety was induced by the administration of a drug or toxin: these included lipopolysaccharide (LPS) (n = 2), streptozotocin (n = 2), corticosterone, kainate and arsenic (n = 1 each) [45,48,50,51,[54][55][56]. In two studies, anxiety was induced by subjecting animals to acute restraint [49,53]. In the remaining seven studies, no method of symptom provocation was used; instead, anxiety-like behaviours were compared across treated and control animals during the performance of specific experimental tasks, such as the open-field test, the elevated plus maze test, the light-dark box test, and the marble burying test [42-44, 46, 47, 53, 57].…”

Stress and the Brain: An Emerging Role for Selenium

“…Using a molecular docking simulation, the authors revealed that MPI may be capable of binding the GCR directly. Finally, Birmann et al (2021) showed that yet another selenocompound, 3,5-dimethyl-1-phenyl-4-(phenylselanyl)-1H-pyrazole (SePy), protects against the anxiogenic-like and hyperalgesic effects of ARS. The authors reported that SePy, which has anti-depressive-like properties (Birmann et al, 2020), prevented the ARS-induced elevation of TBARS levels in the prefrontal cortex and hippocampus, TABLE 1 | Summary of the effects of selenium-containing compounds used in rodent models of stress.…”

“…Therapeutic Effects Against Stress in Rodent Studies (Gai et al, 2014) -Reversed depressant-and anxiety-like behaviors caused by CORT administration -Normalized serum ACTH and CORT levels -Lowered monoamine oxidase-A activity in the PFC -Augmented synaptosomal serotonin and restored GLU uptake in PFC - (Birmann et al, 2021) -Attenuated anxiety-like behavior, allodynia, and hyperalgesia caused by ARS -Normalized plasma CORT levels -Reversed the elevation of ROS and TBARS in the PFC and HPC -Restored SOD activity in the PFC and HPC -May be capable of binding GCR directly 3,5-dimethyl-1-phenyl-4-(phenylselanyl)-1Hpyrazole (SePy) (Birmann et al, 2020) - (Beytut et al, 2018) -Reduced total brain TBARS induced by prednisolone administration -Restored brain GPx activity and levels of reduced GSH -Did not, however, prevent the reduction in CAT activity Sodium Selenite (Na 2 SeO 3 ) (Left column) Selenium-containing compounds used in the reviewed studies and references for preceding studies with those compounds. (Right column) Ameliorative effects of treatment with the selenocompounds against the neurological and physiological impact of various stress paradigms.…”