A puzzling cause of persistent Pseudomonas aeruginosa septicaemia in a patient on maintenance haemodialysis

Chen, Ying Kai; Fang, Hua; Chou, Kang Ju; Lee, Po‐Tsang; Chung, Hsiao Min

doi:10.1093/ndt/gfh367

Cited by 2 publications

(3 citation statements)

References 11 publications

(15 reference statements)

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“…P. aeruginosa is one of the major causes of nosocomial infection, particularly in immunocompromised patients. It has a predilection for moist environments that serve as its natural reservoirs; therefore, P. aeruginosa is a common pathogen in graft infection (Chen et al, 2004;Pham et al, 2019).…”

Section: Backg Rou N Dmentioning

confidence: 99%

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Molecular characterization of clinical isolates from vascular access infection: A single‐institution study

et al. 2020

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Section: Backg Rou N Dmentioning

confidence: 99%

“…It has a predilection for moist environments that serve as its natural reservoirs; therefore, P . aeruginosa is a common pathogen in graft infection (Chen et al, 2004; Pham et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of clinical isolates from vascular access infection: A single‐institution study

et al. 2020

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“…It has a predilection for moist environments that serve as its natural reservoirs; therefore,P. aeruginosa is a common pathogen in graft infection (8,9). We conducted a 5-year single-institution study to (1) investigate the prevalence of bacterial species from VAI (2) determine the molecular characteristics of different bacterial species isolated from various types of VAIs, and (3) establish the correlation between bacterial species, sequence types (STs), and VAI types.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of clinical isolates from vascular access infection: A single institution study

Tseng

Wong

Huang

et al. 2020

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Hemodialysis requires repeated, reliable access to the systemic circulation; therefore, a well-functioning vascular access (VA) procedure is crucial for stable hemodialysis. VA infections (VAIs) constitute the most challenging complication and cause considerable morbidity, loss of access, and even death. In this study, we investigated the molecular profiles of different bacterial isolates retrieved from various types of VA grafts. We collected clinical isolates from hemodialysis patients with VAIs in our institution for the period between 2013 and 2018. We identified the bacterial isolates using standard biochemical procedures; we used a polymerase chain reaction for coagulase-negative staphylococcus (CoNS) and Burkholderia cepacia complex (BCC) species identification. The antibiotic resistance and molecular profile were analyzed using the disk diffusion method and multilocus sequence typing, respectively. We studied 150 isolates retrieved from patients with VAI and observed that Staphylococcus aureus was the predominant bacterial species, followed by S. argenteus, BCC, and CoNS. According to multilocus sequence typing data, we identified a wide variety of sequence types (STs) in S. aureus isolates, with ST59, ST45, and ST239 being the predominant types. Burkholderia cepacia with two new ST types, namely ST1723 and ST1724, accounted for most of the BCC infections, along with ST102 B. contaminans, which were mainly isolated from infected tunneled-cuffed catheters. In summary, the increased incidence of S. argenteus and BCC infections provides insights into their potential clinical effects in VAIs. The various STs identified in different bacterial species indicate the high genetic diversity of bacterial species isolated from VAIs in our institution.

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A puzzling cause of persistent Pseudomonas aeruginosa septicaemia in a patient on maintenance haemodialysis

Cited by 2 publications

References 11 publications

Molecular characterization of clinical isolates from vascular access infection: A single‐institution study

Molecular characterization of clinical isolates from vascular access infection: A single‐institution study

Molecular characterization of clinical isolates from vascular access infection: A single institution study

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