A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non‐Hodgkin's lymphoma

“…Fourthly, stable downregulation of Aurora2/BTAK/STK15 after antisense transfection affects cell survival in vitro and in vivo through a change in the distribution of cell cycle phases. These results seem compatible with the fact that Aurora2/ BTAK/STK15 was originally isolated in centrosomes and the mitotic spindle (Sen et al, 1997). It has been thought that deregulated duplication and distribution of centrosomes might be implicated in the chromosome segregation abnormalities seen in many types of malignant cells.…”

“…This result indicated that Aurora2/BTAK/STK15 may be involved in the cell proliferation of B-cell NHL. As Aurora2/BTAK/STK15 is essential for centrosomes and the mitotic spindle (Sen et al, 1997) and is weakly expressed in normal tissues, we attempted to treat normal fibroblasts with the antisense oligo of Aurora2/BTAK/STK15 and analysed the effect for cell proliferation incorporating [ 3 H] TdR (data not shown). However, there was no downregulation of DNA synthesis in normal fibroblasts even at a high concentration of 10 lmol/l of Aurora2/BTAK/STK15 antisense treatment.…”

“…The Aurora2/BTAK/STK15 gene is localized on chromosome 20q13, the area amplified in a variety of human cancers. Recently, several groups have reported the overexpression of Aurora2/BTAK/STK15 in 12% of primary breast cancers, more than 50% of primary colorectal cancers, and other solid tumour cell lines (Kimura et al, 1997;Sen et al, 1997;Bischoff et al, 1998). Also, overexpression of this kinase in NIH3T3 cells results in aberration in chromosomes and transformation of the cells (Zhou et al, 1998).…”

Function and regulation of Aurora/Ipl1p kinase family in cell division

“…Several studies indicate that Aurora-A has a close link to cancer pathogenesis [64][65][66][67][68]. The Aurora-A gene was mapped to chromosome 20q13.2-13.3, a region often amplified in human cancers [69].…”

“…The Aurora-A gene was mapped to chromosome 20q13.2-13.3, a region often amplified in human cancers [69]. In addition, it has been re-ported that the level of Aurora-A mRNA is high in colon cancer [64,65], as well as in cell lines derived from breast, ovarian, colon, prostate, neuroblastoma and cervical cancers [66]. Ectopic expression of Aurora-A in mouse NIH3T3 cells display the phenotype of abnormal centrosomes replication and cell transformation.…”