A Putative Role for Natriuretic Peptides in Fish Osmoregulation

Dh, Evans; Takei, Yoshiyuki

doi:10.1152/physiologyonline.1992.7.1.15

Cited by 10 publications

(4 citation statements)

References 17 publications

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“…There are several studies on the osmoregulatory actions of ANP in teleost species other than eels, the results of which are not always consistent with those of eels, as summarized in a number of reviews (23,26,51,86). Plasma ANP concentration is generally higher in SW fish than in FW fish or in euryhaline fish that are in SW than in FW (25,31,77,105).…”

Section: Osmoregulatory Actions Of Anp In Fish Other Than Eelsmentioning

confidence: 99%

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Takei

Hirose

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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Takei, Yoshio, and Shigehisa Hirose. The natriuretic peptide system in eels: a key endocrine system for euryhalinity? Am J Physiol Regulatory Integrative Comp Physiol 282: R940-R951, 2002; 10.1152/ajpregu. 00389.2001.-The natriuretic peptide system of a euryhaline teleost, the Japanese eel (Anguilla japonica), consists of three types of hormones [atrial natriuretic peptide (ANP), ventricular natriuretic peptide (VNP), and Ctype natriuretic peptide (CNP)] and four types of receptors [natriuretic peptide receptors (NPR)-A, -B, -C, and -D]. Although ANP is recognized as a volume-regulating hormone that extrudes both Na ϩ and water in mammals, ANP more specifically extrudes Na ϩ in eels. Accumulating evidence shows that ANP is secreted in response to hypernatremia and acts to inhibit the uptake and to stimulate the excretion of Na ϩ but not water, thereby promoting seawater (SW) adaptation. In fact, ANP is secreted immediately after transfer of eels to SW and ameliorates sudden increases in plasma Na ϩ concentration through inhibition of drinking and intestinal absorption of NaCl. ANP also stimulates the secretion of cortisol, a long-acting hormone for SW adaptation, whereas ANP itself disappears quickly from the circulation. Thus ANP is a primary hormone responsible for the initial phase of SW adaptation. By contrast, CNP appears to be a hormone involved in freshwater (FW) adaptation. Recent data show that the gene expression of CNP and its specific receptor, NPR-B, is much enhanced in FW eels. In fact, CNP infusion increases 22 Na uptake from the environment in FW eels. These results show that ANP and CNP, despite high sequence identity, have opposite effects on salinity adaptation in eels. This difference apparently originates from the difference in their specific receptors, ANP for NPR-A and CNP for NPR-B. VNP may compensate the effects of ANP and CNP for adaptation to respective media, because it has high affinity to both receptors. On the basis of these data, the authors suggest that the natriuretic peptide system is a key endocrine system that allows this euryhaline fish to adapt to diverse osmotic environments, particularly in the initial phase of adaptation. atrial natriuretic peptide; ventricular natriuretic peptide; C-type natriuretic peptide; membrane guanylyl cyclase; water and electrolyte balance; molecular evolution; functional evolution; volume regulation; sodium regulation; Anguilla japonica ATRIAL NATRIURETIC PEPTIDE (ANP) was the first member of the natriuretic peptide (NP) family identified in mammals (17,63,69,86). Subsequent to the isolation and sequencing of ANP from the rat atria in 1983, brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) were isolated from the porcine brain in 1988 and 1990, respectively, and they were identified as members of the NP family (Fig. 1). Whereas ANP and BNP are circulating hormones secreted from the heart, CNP is principally a paracrine factor in the brain and periphery (71). The basic structure of the NP peptides consists of an intramolecular...

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Section: Osmoregulatory Actions Of Anp In Fish Other Than Eelsmentioning

confidence: 99%

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Takei

Hirose

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In recent years, the biological role of NPs in the physiology of fish has received much attention and NPs have been shown to affect vascular smooth muscle and gill epithelial function in a variety of species (Evans and Takei, 1992). In elasmobranchs, highaffinity CNP receptors mediate vasodilatation in the branchial arteries of Scyliorhinus canicula (Bjenning et al, 1992) and the ventral aorta of S. acanthias (Evans et al, 1993) and potently stimulate chloride efflux from the rectal gland of S. acanthias (Solomon et al, 1992).…”

mentioning

confidence: 99%

Distribution and Characterization of Natriuretic Peptide Receptors in the Gills of the Spiny Dogfish,Squalus acanthias

Donald

Toop

Evans

1997

General and Comparative Endocrinology

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“…LAMPREY GEOTRIA AUSTRALIS 1800 traditional view that NPs act as saltwater hormones, because the circulating NP concentrations increase during saltwater adaptation (Evans and Takei, 1992), may need to be reappraised in the light of recent data indicating that an upregulation of gill NP receptors occurs in fresh water (Katafuchi et al 1994;Takashima et al 1995;Sakaguchi et al 1996). Such findings become particularly relevant as there is now evidence that NPR-C may be linked with second messenger systems, as opposed to being a 'silent' clearance receptor present only to modulate circulating concentrations of NPs (Maack, 1992;Anand-Srivastava and Trachte, 1993).…”

Section: Natriuretic Peptide Binding Sites In the Gills Of The Pouchedmentioning

confidence: 99%

“…The discovery that a mammalian peptide system was implicated in salt and water balance suggested that NPs might play a role in fish osmoregulation (Evans, 1990). Ensuing studies quickly identified NP immunoreactivity in the heart, plasma and brain of both agnathan and gnathostome fishes and demonstrated vasodilatatory and various iono-and osmoregulatory effects (Evans and Takei, 1992). The precise actions of NPs in fish still await clarification (for general reviews, see Takei and Balment, 1993;Hagiwara et al 1995).…”

mentioning

confidence: 99%

Natriuretic Peptide Binding Sites in the Gills of the Pouched LampreyGeotria Australis

Toop

Grozdanovski²,

Potter³

1998

Journal of Experimental Biology

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Iodinated atrial natriuretic peptide (ANP) binding sites were examined in the gills and ventral aorta of the adult upstream-migrating lamprey Geotria australis using tissue section autoradiography, in vitro competition analysis and affinity cross-linking, while guanylate cyclase assays were performed on gill membranes of both adult and juvenile lampreys. A partial natriuretic peptide (NP) receptor sequence was amplified using reverse transcription/polymerase chain reaction (RT-PCR). The results indicated that there was specific NP binding to the aortic endothelium and to pillar cell regions in the axial plate and secondary lamellae. In competition studies, 50 % of NP binding was abolished by 4 nmol l-1 rat ANP, 35 nmol l-1 porcine C-type NP (CNP) and 45 nmol l-1 C-ANF (a truncated ANP). Affinity cross-linking followed by SDS-PAGE demonstrated two binding sites at 205 and 65 kDa under non-reducing conditions and at 85 and 65 kDa under reducing conditions. Guanylate cyclase assays demonstrated that, while no NP-stimulated GC activity occurred in adult lampreys, NP-stimulated enhancement of cyclic GMP accumulation was found in juveniles in fresh water and more particularly in salt water. RT-PCR amplified a 471 base pair fragment with 68 % amino acid sequence homology to the eel natriuretic peptide receptor D (NPR-D). This study suggests that NP binding sites in the adult gill and aorta are of an NPR-C/D type, whereas an additional GC-coupled site exists in juveniles.

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A Putative Role for Natriuretic Peptides in Fish Osmoregulation

Abstract: Emerging evidence indicates that atrial natriuretic peptide-like peptide hormones may play a significant role in various aspects of fish osmoregulation. Surprisingly, the bulk of current evidence supports a role in salt rather than volume regulation.

Cited by 10 publications

References 17 publications

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

The natriuretic peptide system in eels: a key endocrine system for euryhalinity?

Distribution and Characterization of Natriuretic Peptide Receptors in the Gills of the Spiny Dogfish,Squalus acanthias

Natriuretic Peptide Binding Sites in the Gills of the Pouched LampreyGeotria Australis

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