A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence1,2

Abstract

ABSTRACT:The objective of this study was to detect QTL associated with the incidence of multiple pathogenic diseases in offspring from half-sib bovine families. Four F 1 sires were used to produce offspring: Brahman × Hereford (BH; n = 547), Piedmontese × Angus (PA; n = 209), Brahman × Angus (n = 176), and Belgian Blue × MARC III (n = 246). Treatment records for bovine respiratory disease, infectious keratoconjunctivitis (pinkeye), and infectious pododermatitis (footrot) were available for all of the offspring from birth to slaughter. The incidences of these 3 microbial pathogenic diseases were combined into a single binary trait to represent an overall pathogenic disease incidence. Offspring diagnosed and treated for 1 or more of the previously mentioned pathogenic diseases were coded as a 1 for affected. Cattle with no treatment record were coded as 0 for healthy. A putative QTL for pathogenic disease incidence was detected in the family derived from the BH sire at the genome-wise suggestive level. This was supported by evidence, in the same chromosomal region, of a similar QTL in the family derived from the PA sire. The maximum F-statistic (F = 13.52; P = 0.0003) was located at cM 18. The support interval of the QTL spanned from cM 9 to 28. Further studies should explore this QTL by using other bovine populations to further confirm the QTL and refine the QTL support interval. Offspring inheriting the Hereford allele, in the family from the BH sire, and the Angus allele, in the family from the PA sire, were less susceptible to incidence of pathogenic diseases, when compared with those inheriting the Brahman allele and Piedmontese allele, from the BH and PA sires, respectively.

The F279Y polymorphism of the GHR gene and its relation to milk production and somatic cell score in German Holstein dairy cattle

“…Therefore, the tyrosine allele could be useful in selection to improve resistance to mastitis. The results in the current study are also in line with the repeated mapping of QTL for SCS on chromosome 20 close to the GHR gene (Rodriguez-Zas et al 2002;Ashwell et al 2004;Ron et al 2004;Casas and Snowder 2008).…”

Whole genome analysis of infectious bovine keratoconjunctivitis in Angus cattle using Bayesian threshold models

“…However, results from the nine category analysis additionally identified regions on chromosomes 1 and 20 which accounted for more genetic variance than these regions from analyses of IBK with two and three categories. SNP within the regions on chromosomes 1 and 20 were also found to reside within QTL regions identified by Casas and Stone [3] and within the QTL region on chromosome 20 related to incidence of pathogenic disease that include IBK, bovine respiratory disease, and infectious pododermatitis [7]. Furthermore, SNP within the regions identified in the present study were in regions of QTL for somatic cell count [8].…”

Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide

“…The cluster located on the telomeric region of chromosome 20 has highly significant dominant effects, suggesting that over-dominance may have a role to play in these QTL. Further, this region has also been associated with a number of diseases, including resistance to Mycobacterium avium ssp Paratuberculosis the causative bacterium of Johne's disease [23], bovine keratoconjunctivitis (pinkeye) [24] and respiratory disease and pododermatitis (footrot) [25]. Taken together with the data presented here this suggests that gene(s) located in this region may control the response to several bacterial and viral pathogens, possibly by influencing antibody production.…”