A putative pathway of glyconeogenesis in skeletal muscle

The structure and function of pyruvate kinase

“…The L-type is also allosterically activated by H+ and inhibited by ATP. In contrast the M-type enzyme does not normally possess allosteric properties, although conditions can be found under which it displays kinetic properties typical of a regulatory enzyme (Phillips & Ainsworth, 1977;Odedra & Palmer, 1980). The A-type enzyme has properties intermediate to those of the M-and L-type enzymes.…”