A Putative Nuclear/Nucleolar Signal Sequence Directs the Localization of TRPM7 Kinase

Hill, Ceredwyn E.; Ogunrinde, Adenike; Whetstone, Christiane; Williamson, Evalina

doi:10.1016/j.bpj.2016.11.2214

Cited by 1 publication

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“…In this context, TRPV3 may not be the only TRP channel that is involved in such a complex function and other TRP channels might also be involved in such functions. In this regard, it is worth mentioning that nuclear localization of other TRP channels, including TRPV4 have also been reported 36‐39 . Taken together, we report that TRPV3 is present in the macrophage and involved in bacterial clearance by enhancing lysosomal activity and is possibly involved in the cellular stress response.…”

Section: Discussionsupporting

confidence: 75%

“…In this regard, it is worth mentioning that nuclear localization of other TRP channels, including TRPV4 have also been reported. [36][37][38][39] Taken together, we report that TRPV3 is present in the macrophage and involved in bacterial clearance by enhancing lysosomal activity and is possibly involved in the cellular stress response. This finding may have broad significance in understanding cell stress, lysosomal functions and may have bio-medical application against microbial infection control.…”

Section: Discussionsupporting

confidence: 51%

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Presence of TRPV3 in macrophage lysosomes helps in skin wound healing against bacterial infection

Sahu

Goswami

2022

Experimental Dermatology

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Skin serves as the largest sensory organ that senses multiple sensory cues such as temperature, light, mechanical pressure, presence of noxious compounds, etc. [1][2][3] While the sensitivity of the skin towards certain stimuli differs from species to species, skin architecture and compositions are also highly variable in different species. Skin is the outermost tissue made of several layers of cells and it also acts as the first protective tissue for the internal organs and other tissues. 4,5 Mammalian skin represents a complex sensory as well as protective tissue. Within the skin, critical cross-talks among different cell types (such as neuro-keratinocyte interaction, neuro-immune interactions as well as keratinocyte-immune interactions) are needed for proper skin functions. Abnormalities in all these interactions may lead to skin disorders as well as the development of multiple abnormalities such as sensitization of peripheral neurons and immune system leading to more pain, itch, allergy, inflammation, hypersensitivity, etc. Such changes largely affect the physiology-related behaviours and adaptive fitness of the individual.Irrespective of architectural differences in different species, skin from all the species faces microbial attacks almost routinely.Therefore, the skin serves as the most effective barrier for all the internal organs against most of the physical, chemical, and microbial assaults. This is even more complex as both optimum body temperature and required external temperatures are not identical and differ largely from animal to animal. In a similar context, almost all living habitats ensure bacterial encounters though the extent and diversity of the bacterial groups remain uncertain. Though immune cells,

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Section: Discussionsupporting

confidence: 75%