A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: In vitro and in vivo studies

Guo, Hui; Xia, Dandan; Zheng, Yufeng; Zhu, Yuan; Liu, Yunsong; Zhou, Yongsheng

doi:10.1016/j.actbio.2020.02.024

Cited by 105 publications

(103 citation statements)

References 99 publications

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“…Ti membrane or Ti-reinforced membrane provides excellent mechanical strength for GBR treatment to meet the majority of clinical requirements, especially for vertical ridge augmentation [ 53 ]. A previous study reported that the mechanical properties of pure Zn membranes are inferior to those of pure Ti membrane [ 14 ]. Therefore, in this study, a series of hot-extruded ZnCuFe ternary alloys were fabricated and analyzed.…”

Section: Discussionmentioning

confidence: 99%

“…Particles with too large size can prevent dislocations passing, leading to a dislocation pile-up and the formation of cracks, finally resulting in a decrease in ductility [ 34 ]. Herein, the ZnCuFe (0.2 wt%) alloy showed a good balance between strength and ductility, with a UTS of 202.3 MPa and an elongation at fracture of 41.2%, comparable to those values of pure Ti membrane (Grade I) [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Biodegradable metals (absorbable metals), such as magnesium (Mg), iron (Fe), zinc (Zn) and their alloys, have been considered as revolutionary metallic biomaterials due to their biodegradability, good biocompatibility and mechanical properties [ [9] , [10] , [11] ]. Among them, Zn and Zn-based alloys have recently been considered as the leading candidate materials for biodegradable implants applications [ [12] , [13] , [14] , [15] ]. Zn-based composites and porous scaffolds have also been designed for regenerative purposes in tissue engineering [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Zhang

Li²,

Shen

et al. 2021

Bioactive Materials

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Appropriately adapted comprehensive mechanical properties, degradation behavior and biocompatibility are prerequisites for the application of Zn-based biodegradable implants. In this study, hot-extruded Zn–0.5Cu–xFe (x = 0.1, 0.2 and 0.4 wt%) alloys were fabricated as candidates for biodegradable materials for guided bone regeneration (GBR) membranes. The hot-extrusion process and Cu alloying were expected mostly to enhance the mechanical properties, and the Fe alloying was added mainly for regulating the degradation. The microstructure, mechanical properties and in vitro degradation behavior were systematically investigated. The ZnCuFe alloys were composed of a Zn matrix and FeZn 13 phase. With increasing Fe content, a higher FeZn 13 phase precipitation with larger particles was observed. Since elongation declined significantly until fracture with increasing Fe content up to 0.4 wt%, the ZnCuFe (0.2 wt%) alloy achieved a good balance between mechanical strength and ductility, with an ultimate tensile strength of 202.3 MPa and elongation at fracture of 41.2%. Moreover, the addition of Fe successfully accelerated the degradation of ZnCuFe alloys. The ZnCuFe (0.2 wt%) alloy showed relatively uniform corrosion in the long-term degradation test. Furthermore, extracts of the ZnCuFe (0.2 wt%) alloy showed no apparent cytotoxic effects against L929 fibroblasts, Saos-2 osteoblasts or TAg periosteal cells. The ZnCuFe (0.2 wt%) alloy exhibited the potential to inhibit bacterial adhesion of Streptococcus gordonii and mixed oral bacteria. Our study provides evidence that the ZnCuFe (0.2 wt%) alloy can represent a promising material for the application as a suitable GBR membrane.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Zhang

Li²,

Shen

et al. 2021

Bioactive Materials

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“…prepared three kinds of novel biodegradable pure Zn membranes for GBR: non-porous pure Zn membranes, pure Zn membranes with 300 μm holes, and pure Zn membranes with 1000 μm holes ( Fig. 7 ) [ 210 ]. Except for the pure Zn membranes with 1000 μm pores, the pure Zn membranes showed sufficient mechanical properties and a suitable degradation rate.…”

Section: Mg-based Bms For Oral and Maxillofacial Applicationmentioning

confidence: 99%

“…7 (A) Macroscopic images of three types of pure Zn membranes and pure Ti membranes. (B, C) Representative micro-CT results of rat calvarias covered with three kinds of pure Zn membranes at week 6 and week 10, with a Ti membrane as a control, and a bone defect without a membrane as sham control group [ 210 ]. …”

Section: Mg-based Bms For Oral and Maxillofacial Applicationmentioning

confidence: 99%

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

Xia

Yang

Zheng

et al. 2021

Bioactive Materials

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The oral and maxillofacial regions have complex anatomical structures and different tissue types, which have vital health and aesthetic functions. Biodegradable metals (BMs) is a promising bioactive materials to treat oral and maxillofacial diseases. This review summarizes the research status and future research directions of BMs for oral and maxillofacial applications. Mg-based BMs and Zn-based BMs for bone fracture fixation systems, and guided bone regeneration (GBR) membranes, are discussed in detail. Zn-based BMs with a moderate degradation rate and superior mechanical properties for GBR membranes show great potential for clinical translation. Fe-based BMs have a relatively low degradation rate and insoluble degradation products, which greatly limit their application and clinical translation. Furthermore, we proposed potential future research directions for BMs in the oral and maxillofacial regions, including 3D printed BM bone scaffolds, surface modification for BMs GBR membranes, and BMs containing hydrogels for cartilage regeneration, soft tissue regeneration, and nerve regeneration. Taken together, the progress made in the development of BMs in oral and maxillofacial regions has laid a foundation for further clinical translation.

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Biodegradable Electronics: A Newly Emerging Environmental Technology

Malini¹,

Raj²,

Anantharaju

2022

Biodegradable Materials and Their Applications

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A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: In vitro and in vivo studies

Cited by 105 publications

References 99 publications

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Research status of biodegradable metals designed for oral and maxillofacial applications: A review

Biodegradable Electronics: A Newly Emerging Environmental Technology

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