A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis

Tsujioka, Hiroshi; Hamada, Hitoshi; Miyakawa, Takashi; Hachisuga, Toru; Kawarabayashi, Tatsuhiko

doi:10.1016/s0090-8258(03)00139-2

Cited by 61 publications

(48 citation statements)

References 4 publications

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“…DNA analysis is a reliable method for distinguishing gestational tumors from nongestational tumors. Tsujioka et al 2 reported that the genetic origin could be determined by using only two or three appropriate variable numbers of tandem repeat loci. Our patient had no sexual contact since her husband's death, and therefore we thought that her case may be a NGCO.…”

Section: Discussionmentioning

confidence: 99%

A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman

Park

Kim

et al. 2009

J Gynecol Oncol

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Primary ovarian choriocarcinoma arising from a germ cell is an extremely rare occurrence, especially in postmenopausal women, and the prognosis is poor. Non-gestational choriocarcinoma of the ovary (NGCO) accounts for 0.6% or less of all ovarian neoplasms. It is important to distinguish gestational choriocarcinomas of the ovary (GCO) from other carcinomas because of the poor prognosis of NGCO. We describe a case of NGCO with lung metastasis in a 55 year old woman, which we present together with a brief review of the literature.

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Section: Discussionmentioning

confidence: 99%

A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman

Park

Kim

et al. 2009

J Gynecol Oncol

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“…Human leukocyte antigen typing for the paternal antigen of trophoblast element can be used to determine etiology of gestational choriocarcinoma [10]. DNA polymorphism analysis can be utilized to distinguish pure nongestational choriocarcinoma of the ovary from gestational choriocarcinoma [11,12]. The genetic analysis thus can be a useful modality in determining the origin of the choriocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Choriocarcionoma in an Infantile Patient

Pradjatmo¹

2015

Gen Med (Los Angel)

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Clinical diagnosis of choriocarcinoma may be difficult in post-menopause or children and ectopic origin. According to its histologic origin, it is classified as gestational or nongestational choriocarcinoma. Gestational choriocarcinoma its origin derived from placental trophoblast and nongestational choriocarcinoma-derived from a germ cell. However, DNA and genetic analysis can be used to define the origin of choriocarcinoma. Usually, the DNA examination and genetic analysis have not been used widely in clinical services. In this case the diagnosis to considered as a primary nongestational choriocarcinoma just based on clinical and laboratory finding. This article is aimed to remind the doctors who treat cases choriocarcinoma and is no doubt in deciding whether the origin of the disease from gestational or nongestational should carry out an investigation DNA and genetic analysis.

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“…Nongestational type choriocarcinoma usually involves females under 20, with an average age of 13 years (6,10). Dysgerminoma is the commonest mal ignant germ cell tumour in this age group.…”

Section: Discussionmentioning

confidence: 99%

“…Presence of other germ cell elements is indicative of germ cell choriocarcinoma. Choriocarcinoma of gestational origin can be established by identification of paternal component with the help of DNA analysis which is a reliable method for identifying the genetic origin of pure ovarian choriocarcinomas 10,13,14,15 . However, since such techniques are always expensive and not generally available in our institution,, the application is limited.…”

Section: Discussionmentioning

confidence: 99%