A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Zhang, Jian; Zheng, Yongjun; Lee, Jimmy; Hua, Jieyu; Li, Shilong; Panchamukhi, Ananth; Yue, Jiping; Gou, Xuewen; Xia, Zhaofan; Zhu, Linyong; Wu, Xiaoyang

doi:10.1038/s41467-021-21964-0

Cited by 186 publications

(146 citation statements)

References 62 publications

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“…Another exciting research work focused on scarless wound healing using photoinduced imine-cross-linked sutureless hydrogels that allowed pulsatile release of encapsulated TGF-beta inhibitors. 339 Therein, o-nitrobenzene (NB) was conjugated on PLGA polymer, and PLGA capsules with thick shell and hollow structure for loading and pulsatile release of TGF-beta inhibitor were within easy reach. Meanwhile, partially NB-modified HA was served as pre-gelling polymers to deliver PLGA-NB capsules.…”

Section: Current Advances and Challenges Of Hydrogels In Clinical Or Pre-clinical Applicationsmentioning

confidence: 99%

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Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao

Duan

Yan

et al. 2021

Sig Transduct Target Ther

404

256

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Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) and influence cell signaling cascades and fate. In the past few decades, a plethora of pioneering studies have been implemented to explore the cell–hydrogel matrix interactions and figure out the underlying mechanisms, paving the way to the lab-to-clinic translation of hydrogel-based therapies. In this review, we first introduced the physicochemical properties of hydrogels and their fabrication approaches concisely. Subsequently, the comprehensive description and deep discussion were elucidated, wherein the influences of different hydrogels properties on cell behaviors and cellular signaling events were highlighted. These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling and activation (e.g., Yes-associated protein (YAP), catenin, etc.), cellular compartment reorganization, gene expression, and further cell biology modulation (e.g., spreading, migration, proliferation, lineage commitment, etc.). Based on them, current in vitro and in vivo hydrogel applications that mainly covered diseases models, various cell delivery protocols for tissue regeneration and disease therapy, smart drug carrier, bioimaging, biosensor, and conductive wearable/implantable biodevices, etc. were further summarized and discussed. More significantly, the clinical translation potential and trials of hydrogels were presented, accompanied with which the remaining challenges and future perspectives in this field were emphasized. Collectively, the comprehensive and deep insights in this review will shed light on the design principles of new biomedical hydrogels to understand and modulate cellular processes, which are available for providing significant indications for future hydrogel design and serving for a broad range of biomedical applications.

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Section: Current Advances and Challenges Of Hydrogels In Clinical Or Pre-clinical Applicationsmentioning

confidence: 99%

“…g – m A photoinduced imine-cross-linking hydrogel ( g ) with pulsatile TGF-beta inhibitor release characteristic ( h – k ) for promoting scarless wound healing in rabbit ear scar ( l ) and porcine skin ( m ). 339 Copyright 2021, Springer nature …”

Section: Current Advances and Challenges Of Hydrogels In Clinical Or Pre-clinical Applicationsmentioning

confidence: 99%

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Cao

Duan

Yan

et al. 2021

Sig Transduct Target Ther

404

256

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“…Hydrogel nanocomposites may function as reservoirs for a controlled release of drugs and other molecules necessary for an optimal wound healing. For instance, scar suppression can be achieved by slow pulsatile release of an inhibitor of the transforming growth factor-β (TGFβ) [91]. APOSEC is a novel, innovative drug, able to promote healing of diabetic foot ulcers, and it was included in a hydrogel tested in the phase I/II study MARSYAS II with successful results [92].…”

Section: Drug Releasementioning

confidence: 99%

Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

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“…Recently, various functional hydrogels have been widely used to promote wound healing. [108][109][110][111][112][113][114][115][116][117][118] Chang and coworkers developed a unique bioglass (BG)/oxidized sodium alginate (OSA) composite hydrogel that showed excellent bioactivity to promote vascularization and accelerate tissue regeneration. 119 On the one hand, the BG improves the tissue bonding strength by providing an alkaline microenvironment to stimulate bond formation between the OSA and the amino groups on the surrounding tissue.…”

Section: Wound Healingmentioning

confidence: 99%

Mechanisms and applications of bioinspired underwater/wet adhesives

Cai

Жен

Chen

et al. 2021

Journal of Polymer Science

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In nature, many organisms can effectively fix to contact substrates and move and prey in complex living environments, such as underwater, seawater, and tidal environments, owing to special secreted chemical components and/or special micro/nanostructures on the adhesive surface of these organisms.Inspired by the adhesive performance of organisms, extensive research related to adhesive components and adhesive surfaces has been conducted recently.To better understand the underlying adhesive mechanisms and facilitate further continuous inspiration, a brief overview of recent wet/underwater adhesive materials is provided herein. First, the adhesive processes and underlying mechanisms of commonly researched organisms, such as mussels, octopuses, clingfish, and tree frogs, are discussed, and the corresponding bioinspired artificial adhesives are presented. Then, the applications of these bioinspired adhesives, such as intelligent robots (signal monitoring and sensing devices), wearable devices (including wet climbing and electronic skin), biomedicines (including wound dressings, bone adhesion, and rapid hemostasis), are presented and summarized. Finally, we offer our perspective on the future challenges and development of bioinspired artificial adhesives. K E Y W O R D S adhesive surfaces, applications, artificial components, natural organisms 1 | INTRODUCTION Recently, the development of wet/underwater adhesives inspired by natural organisms has attracted increasing attention and achieved significant progress based on various Chao Cai and Zhen Chen contributed equally to this work

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A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Cited by 186 publications

References 62 publications

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Nanomaterials in Skin Regeneration and Rejuvenation

Mechanisms and applications of bioinspired underwater/wet adhesives

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