2021
DOI: 10.1016/j.medj.2020.10.003
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A Public Health Antibody Screening Indicates a 6-Fold Higher SARS-CoV-2 Exposure Rate than Reported Cases in Children

Abstract: Background Antibody responses to virus reflect exposure and potential protection. Methods We developed a highly specific and sensitive approach to measuring antibodies against SARS-CoV-2 for population-scale immune surveillance. Antibody positivity was defined as a dual-positive response against both the receptor binding domain and nucleocapsid proteins of SARS-CoV-2. Antibodies were measured by immuno-precipitation assays in capillary blood from 15,771 children aged 1 … Show more

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Cited by 111 publications
(136 citation statements)
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“…Moreover, retrospective analysis demonstrates that rates of hospitalization for 2,336 Belgian subjects with T1D do not appear to be increased from February 1 to April 30, 2020, relative to hospitalization numbers for individuals without T1D ( Vangoitsenhoven et al., 2020 ). Similarly, there does not appear to be any relationship between SARS-CoV-2 positivity and development of T1D in children, including individuals at greater risk due to islet autoantibodies ( Hippich et al., 2020 ). Consistent with reduced rates of clinical infection and the generally mild course of COVID-19 in children, the available data do not support T1D as a risk factor for severe COVID-19 in children or adolescents ( Cardona-Hernandez et al., 2020 ).…”
Section: Ketonemia Ketoacidosis and Insulin Deficiencymentioning
confidence: 99%
“…Moreover, retrospective analysis demonstrates that rates of hospitalization for 2,336 Belgian subjects with T1D do not appear to be increased from February 1 to April 30, 2020, relative to hospitalization numbers for individuals without T1D ( Vangoitsenhoven et al., 2020 ). Similarly, there does not appear to be any relationship between SARS-CoV-2 positivity and development of T1D in children, including individuals at greater risk due to islet autoantibodies ( Hippich et al., 2020 ). Consistent with reduced rates of clinical infection and the generally mild course of COVID-19 in children, the available data do not support T1D as a risk factor for severe COVID-19 in children or adolescents ( Cardona-Hernandez et al., 2020 ).…”
Section: Ketonemia Ketoacidosis and Insulin Deficiencymentioning
confidence: 99%
“…9 A recent German study found a high seroprevalence in children compared to health-authority reported cases. 10 However, one cannot exclude the presence of false positives due to beta coronavirus crossreactivity in this study. 10 Second, there may be a time lag in outbreak noti cations due to information gathering processes at the level of the notifying local health o ces.…”
Section: Discussionmentioning
confidence: 87%
“…10 However, one cannot exclude the presence of false positives due to beta coronavirus crossreactivity in this study. 10 Second, there may be a time lag in outbreak noti cations due to information gathering processes at the level of the notifying local health o ces. Third, the quality of reporting in the national surveillance system varies in terms of completeness of data.…”
Section: Discussionmentioning
confidence: 87%
“…Moreover, the user can define the percent of SARS-CoV-2 cases that have actually been diagnosed. The 'percent diagnosed' has been the focus of intense research with highly conflicting predictions [77][78][79][80][81][82] . To date, there is no reliable estimate of this parameter, which is likely influenced by changes in testing strategies and variations in testing capacities over time.…”
Section: Discussionmentioning
confidence: 99%