Pancreatitis is commonly seen with alcohol use and gallstones, but it can be a post-procedural complication from endoscopic retrograde cholangiopancreatography (ERCP). Inflammation of the pancreas can lead to pseudoaneurysm formation, which is rare but extremely dangerous if ruptures, with high mortality and morbidity. Sickle cell disease can also cause vascular injury from repeated vaso-occlusion, inflammation, and ischemia. Here, we present a case of a 27-year-old patient with sickle cell disease who underwent ERCP for stent placement for gallstones and subsequently developed pancreatitis complicated by pseudoaneurysm formation of the inferior pancreaticoduodenal artery (IPDA) that was managed by endovascular embolization.