A Pseudo-TOF Image Reconstruction Approach for Three-Gamma Small Animal Imaging

Giovagnoli, D.; Bousse, Alexandre; Beaupère, N.; Canot, Clotilde; Cussonneau, J. P.; Diglio, S.; Iborra, A.; Masbou, J.; Merlin, Thibaut; Morteau, E.; Xing, Y.; Zhu, Y.; Thers, D.; Visvikis, Dimitris

doi:10.1109/trpms.2020.3046409

Cited by 7 publications

(8 citation statements)

References 39 publications

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“…Some of them have the additional advantage to form theranostic pairs with other isotopes. Among the most promising candidates are 44m Sc, 48 V, 86 Y, 94 Tc, 152 Tb, 34m Cl, or the ones already popular in nuclear medicine in 66 Ga, 72 As, 82 Sr/ 82m Rb or 124 I. The very short-lived isotopes 10 C and 14 O, which have been proposed for online PET monitoring for hadron therapy, are also γ emitters, thus being candidates for this modality.…”

Section: Hybrid Pet/compton Camera Systemsmentioning

confidence: 99%

“…Next, a simple model based on ray-tracing could be further used to compute a i j as the geometrical contribution of the LOR segment to a certain voxel j. In the same way as TOF information is included into PET reconstruction, LM-MLEM can be adapted to three-gamma PET using a Gaussian kernel with weights w i j centered at the LCI [152]. In any case, the uncertainty related to positron range remains.…”

Section: Image Reconstruction Of Hybrid Pet/ccmentioning

confidence: 99%

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Hybrid PET/Compton-camera imaging: an imager for the next generation

Llosá

Rafecas

2023

Eur. Phys. J. Plus

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Compton cameras can offer advantages over gamma cameras for some applications, since they are well suited for multitracer imaging and for imaging high-energy radiotracers, such as those employed in radionuclide therapy. While in conventional clinical settings state-of-the-art Compton cameras cannot compete with well-established methods such as PET and SPECT, there are specific scenarios in which they can constitute an advantageous alternative. The combination of PET and Compton imaging can benefit from the improved resolution and sensitivity of current PET technology and, at the same time, overcome PET limitations in the use of multiple radiotracers. Such a system can provide simultaneous assessment of different radiotracers under identical conditions and reduce errors associated with physical factors that can change between acquisitions. Advances are being made both in instrumentation developments combining PET and Compton cameras for multimodal or three-gamma imaging systems, and in image reconstruction, addressing the challenges imposed by the combination of the two modalities or the new techniques. This review article summarizes the advances made in Compton cameras for medical imaging and their combination with PET.

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Section: Hybrid Pet/compton Camera Systemsmentioning

confidence: 99%

Section: Image Reconstruction Of Hybrid Pet/ccmentioning

confidence: 99%

Hybrid PET/Compton-camera imaging: an imager for the next generation

Llosá

Rafecas

2023

Eur. Phys. J. Plus

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“…The first liquid xenon detector prototypes for PET scans were built and tested around the same time [1224][1225][1226]. Further developments of liquid xenon detectors for PET came recently [1227][1228][1229][1230]. In a PET scan, patients are injected with small amounts of chemicals, such as sugar, where molecules have had common stable carbon atoms replaced with positron-emitting isotopes.…”

Section: J Xenon In Medical Physicsmentioning

confidence: 99%

A Next-Generation Liquid Xenon Observatory for Dark Matter and Neutrino Physics

Aalbers,

Abe,

Aerne

et al. 2022

Preprint

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The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for Weakly Interacting Massive Particles (WIMPs), while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical

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“…The 3-gamma imaging combined with the LXeTPC technology is capable of reconstructing, event-by-event, the position of the (𝛽 + , 𝛾) emitter from each LOR-cone intersection. Compared with the classical PET reconstruction algorithms, the 3-gamma imaging reconstruction algorithm using the cone-LOR intersection criterion constricts the location of the annihilation point on the LOR [3]. The average 33-mm uncertainty along the LOR obtained from a preliminary full GATE/Geant4 simulation represents a significantly higher resolution than conventional PET imaging [3].…”

Section: Introductionmentioning

confidence: 99%