Electronic health (e-health) is becoming a norm in our society, particularly in the current COVID-19 pandemic. Consequently, the volume, variety, velocity and veracity of healthcare data are also increasing. Due to the nature of healthcare data (e.g., patient's medical history and diagnosis), e-health network reliability and security are crucial. While e-health network reliability and security have been the focus of research in recent years, many open research issues remain, particularly as technologies advance. For example, traditional security strategies may not have kept pace with advances in e-health technologies and societal requirements (e.g., increasing privacy regulations). Thus, this special issue presents various state-of-the-art advances and research opportunities on the topics of e-health network reliability and security, covering both theoretical and practical aspects.Specifically, in this special issue twelve (12) research papers were accepted after several rounds of reviews, based on their originality, quality, and merit.The first paper by Pandey et al.[1] presents a solution to detect and thwart the circulation of counterfeit medicines in India through resilient electronic health networks