A proton channel, Otopetrin 1 (OTOP1) is N‐glycosylated at two asparagine residues in third extracellular loop
Omi Sasaki,
Saori Yano‐Nashimoto,
Soichiro Yamaguchi
Abstract:A proton (H+) channel, Otopetrin 1 (OTOP1) is an acid sensor in the sour taste receptor cells. Although OTOP1 is known to be activated by extracellular acid, no posttranslational modification of OTOP1 has been reported. As one of the posttranslational modifications, glycosylation is known to modulate many ion channels. In this study, we investigated whether OTOP1 is glycosylated and how the glycosylation affects OTOP1 function. Pharmacological and enzymatic examinations (using an N‐glycosylation inhibitor, tun… Show more
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