A Protocol for Safe Lithiation Reactions Using Organolithium Reagents

Abstract

Organolithium reagents are powerful tools in the synthetic chemist's toolbox. However, the extreme pyrophoric nature of the most reactive reagents warrants proper technique, thorough training, and proper personal protective equipment. To aid in the training of researchers using organolithium reagents, a thorough, step-by-step protocol for the safe and effective use of tert-butyllithium on an inert gas line or within a glovebox is described. As a model reaction, preparation of lithium tert-butyl amide by the reaction of tert-butyl amine with one equivalent of tertbutyl lithium is presented.

Hydrochromic carbon dots as smart sensors for water sensing in organic solvents

“…[1][2][3][4][5][6] Among the aforementioned targets, the detection and quantication of water in organic solvents has become of utmost importance for numerous industrial applications and has also attracted considerable interest in laboratory safety. [7][8][9] In this context, certain chemical processes must be carefully designed and performed in order to ensure safe operation in scientic laboratories. For instance, water in Grignard reagents can create an exothermic reaction that may cause a ame.…”