A Proteomic Survey of the Cystic Fibrosis Transmembrane Conductance Regulator Surfaceome

Abstract

The aim of this review article is to collate recent contributions of proteomic studies to cystic fibrosis transmembrane conductance regulator (CFTR) biology. We summarize advances from these studies and create an accessible resource for future CFTR proteomic efforts. We focus our attention on the CFTR interaction network at the cell surface, thus generating a CFTR ‘surfaceome’. We review the main findings about CFTR interactions and highlight several functional categories amongst these that could lead to the discovery of potential biomarkers and drug targets for CF.

CFTR dysfunction leads to defective bacterial eradication on cystic fibrosis airways

“…CFTR interacts with many membrane transporters to regulate epithelial function ( Iazzi et al, 2023 ). For example, CFTR modulates the activity of the Na + /H + exchanger (NHE) ( Ahn et al, 2001 ) and Cl − /HCO 3 − exchanger ( Lee et al, 1999 ; Ko et al, 2004 ) to adjust extra- and intracellular pH, implicating the function of these transporters in ASL pH regulation.…”