A Proteomic Study of Memory After Imprinting in the Domestic Chick

Meparishvili, Maia; Nozadze, Maia; Margvelani, Giorgi; McCabe, Brian J.; Solomonia, Revaz

doi:10.3389/fnbeh.2015.00319

Cited by 17 publications

(26 citation statements)

References 86 publications

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“…As regards other tissues, inhibition of miR-130b-3p appears to improve mitochondrial biogenesis signaling 42 and overexpression of this miRNA reduces intracellular levels of ATP 43 . In agreement with these observations, we have shown learning-related increased mitochondrial dynamics and increased amounts of key mitochondrial proteins 24 h after training in the IMM 23 , 24 , 44 .…”

Section: Discussionsupporting

confidence: 89%

“…Removal of SUMO converts CPEB-3 to the aggregated form, which is amyloid-like, can promote translation, and has been proposed to be a functional prion regulating local synaptic protein synthesis necessary for maintenance of hippocampal long-term synaptic plasticity 48 . We have shown that another protein containing a prion-like domain is up-regulated in a learning-related way in the left IMM 24 h after imprinting training 23 . This protein is heterogeneous nuclear ribonucleoprotein A2/B1, which is involved in the delivery and translation of mRNAs into dendrites.…”

Section: Discussionmentioning

confidence: 80%

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Micro-RNAs, their target proteins, predispositions and the memory of filial imprinting

Margvelani

Meparishvili

Kiguradze³

et al. 2018

Sci Rep

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Visual imprinting is a learning process whereby young animals come to prefer a visual stimulus after exposure to it (training). The intermediate medial mesopallium (IMM) in the domestic chick forebrain is critical for visual imprinting and contributes to molecular regulation of memory formation. We investigated the role of micro-RNAs (miRNAs) in such regulation. Twenty-four hours after training, miRNA spectra in the left IMM were compared between chicks with high preference scores (strong memory for imprinting stimulus), and chicks with low preference scores (weak memory for imprinting stimulus). Using criteria of significance and expression level, we chose gga-miR-130b-3p for further study and found that down-regulation correlated with learning strength. No effect was detected in posterior nidopallium, a region not involved in imprinting. We studied two targets of gga-miR-130b-3p, cytoplasmic polyadenylation element binding proteins 1 (CPEB-1) and 3 (CPEB-3), in two subcellular fractions (P2 membrane-mitochondrial and cytoplasmic) of IMM and posterior nidopallium. Only in the left IMM was a learning-related effect observed, in membrane CPEB-3. Variances from the regression with preference score and untrained chicks suggest that, in the IMM, gga-miR-130b-3p level reflects a predisposition, i.e. capacity to learn, whereas P2 membrane-mitochondrial CPEB-3 is up-regulated in a learning-specific way.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 80%

Micro-RNAs, their target proteins, predispositions and the memory of filial imprinting

Margvelani

Meparishvili

Kiguradze³

et al. 2018

Sci Rep

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“…Instead, we controlled loading by Ponceau S staining and calibrated all gels with the same protein standards (see above and also [30]).…”

Section: Methodsmentioning

confidence: 99%

Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus

Tsverava

Lordkipanidze

Lepsveridze

et al. 2016

BioMed Research International

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Identification of compounds preventing or modifying the biochemical changes that underlie the epileptogenesis process and understanding the mechanism of their action are of great importance. We have previously shown that myoinositol (MI) daily treatment for 28 days prevents certain biochemical changes that are triggered by kainic acid (KA) induced status epilepticus (SE). However in these studies we have not detected any effects of MI on the first day after SE. In the present study we broadened our research and focused on other molecular and morphological changes at the early stages of SE induced by KA and effects of MI treatment on these changes. The increase in the amount of voltage-dependent anionic channel-1 (VDAC-1), cofilin, and caspase-3 activity was observed in the hippocampus of KA treated rats. Administration of MI 4 hours later after KA treatment abolishes these changes, whereas diazepam treatment by the same time schedule has no significant influence. The number of neuronal cells in CA1 and CA3 subfields of hippocampus is decreased after KA induced SE and MI posttreatment significantly attenuates this reduction. No significant changes are observed in the neocortex. Obtained results indicate that MI posttreatment after KA induced SE could successfully target the biochemical processes involved in apoptosis, reduces cell loss, and can be successfully used in the future for translational research.

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“…An up-regulation of the NMDA subtype of glutamate receptor that is correlated with preference score is also observed, restricted to the left IMM (McCabe and Horn, 1988). In the late period (>15 h after the end of training), there is evidence of trophic changes and synaptic stabilization approximately in proportion to the amount learned by the chicks, namely up-regulation of neural cell adhesion molecules (Solomonia et al., 1998), clathrin (Solomonia et al., 1997) and amyloid precursor protein (Solomonia et al., 2003) and cognin/brain spectrin (Meparishvili et al., 2015). Other learning-related changes at this time are suggestive of membrane and cytoskeletal stabilization, implicating alpha-fodrin (Solomonia et al., 2011) and MARCKS (Solomonia et al., 2003, 2008).…”

Section: Physiological Mechanismsmentioning

confidence: 99%

Visual Imprinting in Birds: Behavior, Models, and Neural Mechanisms

McCabe

2019

Front. Physiol.

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Filial imprinting is a process, readily observed in precocial birds, whereby a social attachment is established between a young animal and an object that is typically (although not necessarily) a parent. During a perinatal sensitive period, the young animal learns characteristics of the object (the imprinting stimulus) simply by being exposed to it and will subsequently recognize and selectively approach this stimulus. Imprinting can thus establish a filial bond with an individual adult: a form of social cohesion that may be crucial for survival. Behavioral predispositions can act together with the learning process of imprinting in the formation, maintenance, and modification of the filial bond. Memory of the imprinting stimulus, as well as being necessary for social recognition, is also used adaptively in perceptual classification of sensory signals. Abstract features of an imprinting stimulus, such as similarity or difference between stimulus components, can also be recognized. Studies of domestic chicks have elucidated the neural basis of much of the above behavior. This article discusses (1) principal behavioral characteristics of filial imprinting and related predispositions, (2) theoretical models that have been developed to account for this behavior, and (3) physiological results elucidating the underlying neural mechanisms. Interactions between these different levels of analysis have resulted in advancement of all of them. Taken together, the different approaches have helped define strategies for investigating mechanisms of learning, memory, and perception.

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A Proteomic Study of Memory After Imprinting in the Domestic Chick

Cited by 17 publications

References 86 publications

Micro-RNAs, their target proteins, predispositions and the memory of filial imprinting

Micro-RNAs, their target proteins, predispositions and the memory of filial imprinting

Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus

Visual Imprinting in Birds: Behavior, Models, and Neural Mechanisms

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