A proteomic atlas of kidney amyloidosis provides insights into disease pathogenesis

Charalampous, Charalampos; Dasari, Surendra; McPhail, Ellen; Theis, Jason D.; Vrana, Julie A.; Dispenzieri, Angela; Leung, Nelson; Muchtar, Eli; Gertz, Morie; Ramirez-Alvarado, Marina; Kourelis, Taxiarchis

doi:10.1016/j.kint.2023.11.023

Cited by 3 publications

(3 citation statements)

References 64 publications

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“…Proteins deposited in amyloid plaques (expanded proteome) and proteins overexpressed in plaques compared to controls (plaque-specific proteome) have been investigated in 2650 cases from eight different types of kidney amyloidosis [immunoglobulin light chain (AL), heavy chain (AH), a mix of heavy and light chain amyloid (IGH), ALECT2, AA, AFib, AApoAIV, and AApoCII] using laser microdissection–mass spectrometry. The proteomic content was higher in the more indolent types of amyloid (non-AL) than in AL [ 12 ]. The proteomic “density” of amyloid plaques can serve as an indicator of more gradual disease progression [ 13 ].…”

Section: Characterizing Proteomic Variations In Amyloidosismentioning

confidence: 99%

“…Finally, the accumulation behavior of amyloidogenic proteins is independent of other proteins, suggesting that kidney toxicity in this condition cannot be solely attributed to amyloid levels. Investigating the functions of the proteins regarding disease development could provide a foundation for creating new treatments [ 12 ].…”

Section: Characterizing Proteomic Variations In Amyloidosismentioning

confidence: 99%

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Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes

Delrue,

Dendooven,

Vandendriessche

et al. 2024

IJMS

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Renal amyloidosis is a set of complex disorders characterized by the deposition of amyloid proteins in the kidneys, which causes gradual organ damage and potential kidney failure. Recent developments in diagnostic methods, particularly mass spectrometry and proteome profiling, have greatly improved the accuracy of amyloid typing, which is critical for disease management. These technologies provide extensive insights into the specific proteins involved, allowing for more targeted treatment approaches and better patient results. Despite these advances, problems remain, owing to the heterogeneous composition of amyloid proteins and the varying efficacy of treatments based on amyloid type. Access to sophisticated diagnostics and therapy varies greatly, highlighting the global difference in renal amyloidosis management. Future research is needed to investigate next-generation sequencing and gene-editing technologies, like clustered regularly interspaced short palindromic repeats (CRISPR), which promise more profound insights into the genetic basis of amyloidosis.

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Section: Characterizing Proteomic Variations In Amyloidosismentioning

confidence: 99%

Section: Characterizing Proteomic Variations In Amyloidosismentioning

confidence: 99%

Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes

Delrue,

Dendooven,

Vandendriessche

et al. 2024

IJMS

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“…Neuere Daten zeigen, dass eine Reihe weiterer Proteine wie z. B. des Komplementsystems ebenfalls rekrutiert werden und die Toxizität auch durch die Nicht-Amyloid-Proteine bestimmt wird [11]. Das jahrelang geäußerte Mantra, dass abgelagertes Amyloid inert ist und weder pharmakologisch noch physiologisch entfernt werden kann, ist heute nicht mehr gültig.…”

Section: Pathogenese Der Amyloidbildungunclassified

Renale Amyloidosen

Gaedeke

2024

Nephrologie aktuell

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ZUSAMMENFASSUNGDie Amyloidosen sind eine Gruppe von seltenen Erkrankungen, die sich durch die Bildung und Ablagerung von aberrant gefalteten Proteinen definieren. Grundsätzlich können sowohl Mutationen als auch die Überproduktion von Proteinen den komplexen Prozess der Amyloidogenese starten. Krankheitswert bekommen diese Ablagerungen teilweise durch direkte zytotoxische Effekte, größtenteils jedoch durch eine mechanische Störung der Organarchitektur (z. B. Ablagerung in der glomerulären Basalmembran). Die Diagnose wird oft erst in späteren Stadien über einen manifesten Organschaden (z. B. Proteinurie) gestellt. Die Klinik wird wesentlich von der Art des Vorläuferproteins beziehungsweise der daraus folgenden Organlokalisation bestimmt. Das Überleben hängt bei vielen Amyloidoseerkrankungen vom Grad der kardialen Beteiligung ab. Etablierte Therapiestrategien zielen vor allem auf die Produktionshemmung der Vorläuferproteine ab; experimentelle Ansätze verfolgen das Ziel, bereits abgelagertes Amyloid aufzulösen.

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Mining the amyloid-plaque proteome to uncover disease mechanisms in renal amyloidoses

Nuvolone,

Merlini

2024

Kidney International

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A proteomic atlas of kidney amyloidosis provides insights into disease pathogenesis

Cited by 3 publications

References 64 publications

Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes

Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes

Renale Amyloidosen

Mining the amyloid-plaque proteome to uncover disease mechanisms in renal amyloidoses

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