A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium

Yonezawa, Daiki; Sekiguchi, Fumiko; Miyamoto, Misato; Taniguchi, Eiichi; Honjo, Masami; Masuko, Takashi; Nishikawa, Hiroyuki; Kawabata, Atsufumi

doi:10.1016/j.tox.2007.07.020

Cited by 109 publications

(79 citation statements)

References 34 publications

(49 reference statements)

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“…Genomic DNA extraction, PCR, and gene annotation were conducted according to the previous studies (Yoon et al 2013;Jeon and Park 2015;Rahman et al 2016). Previously published mitogenomes of the Eurasian M. meles (AM711900) (Arnason et al 2007) and Japanese M. anakuma (AB291075) (Yonezawa et al 2007) were used as references for gene annotation and primer design for PCR amplification of the Korean M. leucurus. Phylogenetic tree was constructed using maximum likelihood (ML) procedures implemented in MEGA6 (Tamura et al 2013).…”

mentioning

confidence: 99%

Complete mitochondrial genome of the Asian badger Meles leucurus (Mustelidae) from Korea

Jeon

Kim²,

Min

et al. 2017

Mitochondrial DNA Part B

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The mitogenome of the Asian badger Meles leucurus from Korea is a circular molecule of 16,529 bp, consisting of a control region and a conserved set of 37 genes containing 13 protein-coding genes (PCGs), 22 tRNA genes, and two rRNA genes ( 12S rRNA and 16S rRNA ). The mitogenome of M. leucurus is AT-biased, with a nucleotide composition of 33.1% A, 27.9% T, 25.4% C, and 13.5% G. The phylogenetic analysis revealed that the badger M. leucurus from Korea is well grouped with that from China, forming a sister clade to M. meles from Japan.

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mentioning

confidence: 99%

Complete mitochondrial genome of the Asian badger Meles leucurus (Mustelidae) from Korea

Jeon

Kim²,

Min

et al. 2017

Mitochondrial DNA Part B

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“…H 2 S most likely regulates MMP/TIMP changes through these anti- [33] . Two studies reported that at low levels, H 2 S defends organs from several pathophysiological conditions, such as oxidative stress and ischemia-reperfusion [34,35] . The antioxidant property of H 2 S was partly mediated by increasing intracellular catalase (CAT) and superoxide dismutase (SOD), which are the most efficient enzymatic antioxidants [36,37] .…”

Section: Discussionmentioning

confidence: 99%

Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload

Zhang

et al. 2013

Acta Pharmacol Sin

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Aim: To study the effects of hydrogen sulfide (H 2 S) on the left ventricular expression of MMP-8, MMP-13, and TIMP-1 in a rat model of congenital heart disease. Methods: Male SD rats underwent abdominal aorta-inferior vena cava shunt operation. H 2 S donor NaHS (56 μmol·kg -1 ·d -1, ip) was injected from the next day for 8 weeks. At 8 weeks, the hemodynamic parameters, including the left ventricular systolic pressure (LVSP), the left ventricular peak rate of contraction and relaxation (LV±dp/dt max ) and the left ventricular end diastolic pressure (LVEDP) were measured. The left ventricular tissues were dissected out, and hydroxyproline and collagen I contents were detected with ELISA. The expression of MMP-8, MMP-13, and a tissue inhibitor of metalloproteinase-1 (TIMP-1) in the tissues was measured using real-time PCR, Western blotting, and immunohistochemistry, respectively. Results: The shunt operation markedly reduced LVSP and LV±dp/dt max , increased LVEDP, hydroxyproline and collagen I contents, as well as the mRNA and protein levels of MMP-8, MMP-13, and TIMP-1 in the left ventricles. Chronic treatment of the shunt operation rats with NaHS effectively prevented the abnormalities in the hemodynamic parameters, hydroxyproline and collagen I contents, and the mRNA and protein levels of MMP-13 and TIMP-1 in the left ventricles. NaHS also prevented the increase of MMP-8 protein expression, but did not affect the increase of mRNA level of MMP-8 in the shunt operation rats. Conclusion: H 2 S suppresses protein and mRNA expression of MMP-8, MMP-13, and TIMP-1 in rats with cardiac volume overload, which may be contributed to the amelioration of ventricular structural remodeling and cardiac function.

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“…H2S insures protection against ROS stress in gastric mucosal epithelia [22]. Accelerates gastric ulcer healing [107].…”

Section: Other Organ Effectsmentioning

confidence: 99%

“…Moreover, after the discovery of nitric oxide (NO) and carbon oxide (CO), hydrogen sulfide (H 2 S) is the third gaseous signaling messenger found in mammalian tissues [18]. H 2 S is a reducing molecule displaying strong scavenging properties as animal experiments and tissue cultures demonstrate that exogenous supply of the gasotransmitter significantly attenuates [19,20] or even abolishes [21,22] the oxidative injury imposed by HHcy burden. The endogenous production of the naturally occurring H 2 S reductant depends on Cys bioavailability through the mediation of TS enzymes [23,24].…”

mentioning

confidence: 99%

The Oxidative Stress of Hyperhomocysteinemia Results from Reduced Bioavailability of Sulfur-Containing Reductants

Ingenbleek¹

2011

TOCCHEMJ

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Vegetarian subjects consuming subnormal amounts of methionine (Met) are characterized by subclinical protein malnutrition causing reduction in size of their lean body mass (LBM) best identified by the serial measurement of plasma transthyretin (TTR). As a result, the transsulfuration pathway is depressed at cystathionine--synthase (C S) level triggering the upstream sequestration of homocysteine (Hcy) in biological fluids and promoting its conversion to Met. Maintenance of beneficial Met homeostasis is counterpoised by the drop of cysteine (Cys) and glutathione (GSH) values downstream to C S causing in turn declining generation of hydrogen sulfide (H 2 S) from enzymatic sources. The biogenesis of H 2 S via non-enzymatic reduction is further inhibited in areas where earth's crust is depleted in elemental sulfur (S 8 ) and sulfate oxyanions. Combination of subclinical malnutrition and S 8 -deficiency thus maximizes the defective production of Cys, GSH and H 2 S reductants, explaining persistence of unabated oxidative burden. The clinical entity increases the risk of developing cardiovascular diseases (CVD) and stroke in underprivileged plant-eating populations regardless of Framingham criteria and vitamin-B status. Although unrecognized up to now, the nutritional disorder is one of the commonest worldwide, reaching top prevalence in populated regions of Southeastern Asia. Increased risk of hyperhomocysteinemia and oxidative stress may also affect individuals suffering from intestinal malabsorption or westernized communities having adopted vegan dietary lifestyles.

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A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium

Cited by 109 publications

References 34 publications

Complete mitochondrial genome of the Asian badger Meles leucurus (Mustelidae) from Korea

Complete mitochondrial genome of the Asian badger Meles leucurus (Mustelidae) from Korea

Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload

The Oxidative Stress of Hyperhomocysteinemia Results from Reduced Bioavailability of Sulfur-Containing Reductants

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