A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice.

Abstract

SummaryWe have previously reported that T cells bearing T cell receptors (TCRs) of 3`//$ type appear at a relatively early stage of primary infection with Listeria monocytogenes in mice. To characterize the early-appearing 3`//$ T cells during listeriosis, we analyzed the specificity and cytokine production of the 3`//$ T cells in the peritoneal cavity in mice inoculated intraperitoneally with a sublethal dose of L. monocytogenes. The early-appearing 3'//$ T cells, most of which were of CD4-CD8-phenotype, proliferated and secreted IFN-3' and macrophage chemotactic factor in response to purified protein derivative from Mycobacterium tuberculosis, or recombinant 65-kD heat-shock protein derived from M. bov/s but not to heat-killed Listeria.

Retracted: α‐GalCer ameliorates listeriosis by accelerating infiltration of Gr‐1+ cells into the liver

“…Consistent with previous findings [19][20][21][22], g/d T cells were numerically increased after L. monocytogenes infection. Although participation of g/d T cells in protection against L. monocytogenes has been suggested [19][20][21][22], depletion of g/d T cells did not increase susceptibility of untreated mice to L. monocytogenes infection in this study.…”

“…Therefore, regulating the number of Gr-1 1 cells in the liver and prompt removal of senescent Gr-1 1 cells may be important for maintaining normal immune function and preventing tissue injury. We therefore assume that the numerical reduction of CD11b 1 Gr-1 1 cells in a-GalCer-treated mice after L. monocytogenes infection is the result of prompt bacterial clearance by CD11b 1 Gr-1 1 cells induced by a-GalCer.Consistent with previous findings [19][20][21][22], g/d T cells were numerically increased after L. monocytogenes infection. Although participation of g/d T cells in protection against L. monocytogenes has been suggested [19][20][21][22], depletion of g/d T cells did not increase susceptibility of untreated mice to L. monocytogenes infection in this study.…”

“…g/d T cells have been shown to contribute to prompt defense against L. monocytogenes infection [19][20][21][22]. Hence, we compared numbers of g/d T cells in the liver before and after a-GalCer treatment.…”

“…G-CSF is indispensable for both steady-state and emergency granulopoiesis [11][12][13][14], and IL-17 regulates G-CSF secretion [9,10,[15][16][17][18]. In addition to Gr-1 1 cells, g/d T cells also participate in early protection against L. monocytogenes infection [19][20][21][22]. The vast majority of L. monocytogenes organisms are trapped in the liver immediately after systemic infection [23] and hence, immunocompetent cells that reside in, and/or migrate into, the liver are critical for infection control.…”

Role of Heat Shock Proteins in Diseases and Their Therapeutic Potential

“…Hsp60 reactive cS T cells and hsp70 reactive cS T cells are specifically activated in experimental listeriosis of mice and conferred protection against Listeria monocytogenes infection. It has been shown that, depletion of cd T cells with monoclonal antibodies has led to increased listerial multiplication in mice [42].…”