A protective effect of adiponectin against oxidative stress in Japanese Americans: the association between adiponectin or leptin and urinary isoprostane

Nakanishi, Shuhei; Yamane, Kiminori; Kamei, Nozomu; Nojima, Hideki; Okubo, Masamichi; Kohno, Nobuoki

doi:10.1016/j.metabol.2004.08.012

Cited by 106 publications

(82 citation statements)

References 28 publications

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“…16 A recent study in Japanese Americans showed lower levels of adiponectin in IGT subjects than in NGT subjects, although the difference was not statistically significant. 17 However, those studies included both men and women, and there is a significant gender difference in adiponectin levels. 12 Furthermore, precise evaluation including the presence or absence of CAD in non-diabetic subjects has not been performed.…”

Section: Discussionmentioning

confidence: 99%

Hypoadiponectinemia is Associated With Impaired Glucose Tolerance and Coronary Artery Disease in Non-Diabetic Men

Otsuka

Sugiyama

Kojima

et al. 2007

Circ J

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Section: Discussionmentioning

confidence: 99%

Hypoadiponectinemia is Associated With Impaired Glucose Tolerance and Coronary Artery Disease in Non-Diabetic Men

Otsuka

Sugiyama

Kojima

et al. 2007

Circ J

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“…Evidence has been also published to show that circulating adiponectin binds to the vascular wall of catheter-injured vessels, although the functional implications of this observation for vascular homeostasis are not known (42). More mechanistic studies in vitro have demonstrated that this adipokine is provided with antiinflammatory properties against oxidative stress and the action of cytokines (18,43), suggesting that inhibition of inflammatory signals is the fundamental mechanism of the vascular protective actions of adiponectin in vivo.…”

Section: Group (N) No (Pmol/mg Tissue)mentioning

confidence: 99%

Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo

Ouedraogo¹,

Gong²,

Berzins³

et al. 2007

J. Clin. Invest.

242

149

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This study reports on what we believe are novel mechanism(s) of the vascular protective action of adiponectin. We used intravital microscopy to measure leukocyte-endothelium interactions in adiponectin-deficient (Ad -/-) mice and found that adiponectin deficiency was associated with a 2-fold increase in leukocyte rolling and a 5-fold increase in leukocyte adhesion in the microcirculation. Measurement of endothelial NO (eNO) revealed that adiponectin deficiency drastically reduced levels of eNO in the vascular wall. Immunohistochemistry demonstrated increased expression of E-selectin and VCAM-1 in the vascular endothelium of Ad -/-mice. Systemic administration of the recombinant globular adiponectin domain (gAd) to Ad -/-mice significantly attenuated leukocyte-endothelium interactions and adhesion molecule expression in addition to restoring physiologic levels of eNO. Importantly, prior administration of gAd also protected WT mice against TNF-α-induced leukocyte-endothelium interactions, indicating a pharmacologic action of gAd. Mechanistically, blockade of eNOS with N ω -nitro-l-arginine methyl ester (l-NAME) abolished the inhibitory effect of gAd on leukocyte adhesion, demonstrating the obligatory role of eNOS signaling in the antiinflammatory action of gAd. We believe this is the first demonstration that gAd protects the vasculature in vivo via increased NO bioavailability with suppression of leukocyte-endothelium interactions. Overall, we provide evidence that loss of adiponectin induces a primary state of endothelial dysfunction with increased leukocyte-endothelium adhesiveness.

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“…Oxidative stress stimulates the expression of VEGF and FGF-2 genes in adipocytes (Lolmede et al 2003). Leptin, the major adipokine secreted from hypertrophic adipocytes, induces oxidative stress, and its concentration in plasma has a positive correlation with oxidative stress levels (Nakanishi et al 2005). We have shown that the expression of adipokine genes (VEGF, FGF-2, and leptin) in the mesenteric adipose tissue was significantly lower in the HV group than in the CT group (Fig.…”

Section: Effects Of Wcrs On Adipokine Gene Expressionmentioning

confidence: 71%

Effects of Whole Crop Rice Silage on Meat Quality and Adipokine Gene Expression in Fattening <i>Wagyu</i> Cattle

Yamada

Higuchi

Nakanishi

2017

JARQ

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The objective of this study was to investigate the effects of whole crop rice silage (WCRS) feeding on the lipid stability of beef and fat depot-specific adipokine gene expression patterns in Wagyu cattle. Wagyu steers were fed a control diet (CT, n=4) or a high-vitamin diet containing WCRS (HV, n=4) from 10 to 30 months of age. The α-tocopherol concentration of the longissimus muscle was significantly higher in the HV group than in the CT group. The percentage of metmyoglobin in the longissimus muscle was significantly lower in the HV group than in the CT group. The 2-Thiobarbituric acid-reactive substance values of the longissimus muscle were also significantly lower in the HV group than in the CT group. The plasma 8-isoprostane concentration, which is a biomarker of oxidative stress, was significantly lower in the HV group than in the CT group. The expression of adipokine genes (VEGF, FGF-2, and leptin) in mesenteric adipose tissue was significantly lower in the HV group than in the CT group. These results suggest that feeding beef cattle on WCRS improves both the quality of meat and the oxidative stress status.

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A protective effect of adiponectin against oxidative stress in Japanese Americans: the association between adiponectin or leptin and urinary isoprostane

Cited by 106 publications

References 28 publications

Hypoadiponectinemia is Associated With Impaired Glucose Tolerance and Coronary Artery Disease in Non-Diabetic Men

Hypoadiponectinemia is Associated With Impaired Glucose Tolerance and Coronary Artery Disease in Non-Diabetic Men

Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo

Effects of Whole Crop Rice Silage on Meat Quality and Adipokine Gene Expression in Fattening <i>Wagyu</i> Cattle

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