A prospective surgical pathological study of stage I squamous carcinoma of the cervix: A Gynecologic Oncology Group study

Delgado, Gregorio; Bundy, Brian N.; Fowler, Wesley C.; Stehman, Frederick B.; Sevin, Bernd‐Uwe; Creasman, William T.; Major, Francis J.; DiSaia, Philip J.; Zaino, Richard J.

doi:10.1016/0090-8258(89)90070-x

Cited by 359 publications

(242 citation statements)

References 7 publications

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“…As a matter of fact radical lymph node dissection during surgery in early stage cervical cancer is discussed controversially (Kinney et al, 1995;Shingleton, 1998;Magrina et al, 1999). For instance, cervical tumour size less than 2 cm has been associated with nodal metastases in only 0-16% of cases (Delgado et al, 1989;Magrina et al, 1999). Recently some authors described the sentinel node procedure in cervical cancer by blue dye uptake (Echt et al, 1999;Dargent et al, 2000;Medl et al, 2000;O'Boyle et al, 2000) or by lymphoscintigraphy (Kamprath et al, 2000), whereas some authors used both techniques to detect SLNs in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Radical hysterectomy with pelvic lymphadenectomy is the most commonly performed definitive surgical procedure for patients with Figo IB cervical cancer. Few of these patients do have pelvic lymph node metastasis (Delgado et al, 1989;Magrinal et al, 1999), but many patients with radical lymph node resection suffer from side effects after surgery. Therefore some investigators recommended a less radical approach for early cervical cancer with precise preoperative determination of lymph node metastases (Kinney et al, 1995;Shingleton, 1998;Magrina et al, 1999).…”

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confidence: 99%

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Sentinel node procedure in Ib cervical cancer: a preliminary series

et al. 2001

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The aim of this study was to determine the diagnostic accuracy and feasibility of sentinel lymph node (SLN) detection using a gamma probe in patients with Figo IB cervical cancer. Between January 1999 and September 2000, 14 patients with cervical cancer, planned for radical hysterectomy were eligible for the study. The day before radical hysterectomy we injected technetium 99 m-labelled nanocolloid in each quadrant of the cervix. Dynamic and static images were recorded using a gamma camera. SLNs were identified intraoperatively using a handheld gamma-detection probe. After resection of SLNs a standard radical hysterectomy with pelvic lymph node dissection was performed. Patients and tumour characteristics were compared with sentinel node detection and with final histopathological and immunohistochemical results. Scintigraphy showed focal uptake in 13 of the 14 patients. Intraoperatively we detected 26 sentinel nodes by gamma probe. In 8 of 13 patients, one or more sentinel nodes were identified unilaterally, in 5 women bilaterally. Histologically positive SLNs were found in only 1 patient. We did not find any false-negative SLN in our series. In conclusion identification of sentinel nodes in cervical cancer is feasible with preoperatively administered technetium 99 m-labelled nanocolloid. A larger series will be required to establish sentinel node detection in cervical cancer for further therapy concepts and planning. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Sentinel node procedure in Ib cervical cancer: a preliminary series

et al. 2001

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“…Positive or close vaginal surgical margin has been regarded as one of high-risk pathological factors associated with increased recurrence and decreased survival in early-stage cervical cancer following radical surgery (Delgado et al, 1989;Randall et al, 2013). In the recent study by McCann et al (2013), although not an independent predicting factor for recurrence, close vaginal margin of ≤5 mm was associated with other high or intermediate-risk pathological factors including nodal metastasis, parametrial involvement, larger tumor, deeper cervical stromal invasion, and LVSI.…”

Section: Discussionmentioning

confidence: 99%

“…However, certain pathological characteristics have been regarded as high-risk factors for recurrence and decreased survival. These include pelvic node metastasis, parametrial extension, and positive or close surgical margins (Delgado et al, 1989;Randall et al, 2013). It has been generally recommended that adjuvant pelvic radiation with or without concurrent chemotherapy be given to the patients with any of these high-risk pathological factors.…”

Section: Introductionmentioning

confidence: 99%

Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix

Sethasathien

Charoenkwan²,

Settakorn³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…El compromiso del parametrio contiguo al cérvix representa el sitio más frecuente de diseminación local (6 a 31% en EC IB) y se produce mediante la extensión microscópica directa o mediante permeación de émbolos tumorales por vía linfovascular (7)(8)(9)(10) . Por lo tanto, la eliminación del tejido parametrial (parametrectomía) ha sido considerada como parte del manejo quirúrgico estándar de cáncer de cérvix.…”

Section: Introductionunclassified

Compromiso parametrial en pacientes con cáncer de Cérvix IB-1 tratadas con histerectomía radical en Perú

Urrutia

Santos

Zevallos

et al. 2014

Rev Peru Med Exp Salud Publica

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Objetivos. Evaluar la frecuencia y factores asociados al compromiso parametrial (CP) en pacientes con cáncer de cérvix IB-1 sometidas a histerectomía radical (HR) en el Instituto Nacional de Enfermedades Neoplásicas del Perú. Materiales y métodos. Estudio transversal analítico en 214 pacientes con cáncer de cérvix IB-1 sometidas a HR con linfadenectomía pélvica entre el 2007 y 2012. Se comparó la población con y sin CP según variables clinicopatológicas como edad, tamaño tumoral, profundidad de infiltración, grado histológico y afectación ganglionar pélvica. Resultados. Diez pacientes (4,6%) presentaron CP. El análisis multivariable mostró que la profundidad de la invasión (OR 8,37, IC 95%: 1,41, p=0,029) y el compromiso de ganglios pélvicos (OR 18,03, IC 95%: 3,44, p=0,001) resultaron ser predictores independientes del CP. La presencia de tamaño tumoral ≤ 2 cm, invasión ≤ 10 mm, ausencia de permeación linfovascular y ausencia de compromiso ganglionar permitió identificar 97 pacientes de bajo riesgo de CP, de los cuales ninguno tuvo CP en patología. Conclusiones. Confirmamos la baja frecuencia del CP en el subgrupo de cáncer de cervix IB-1 y su asociación con la profundidad de la invasión y con el compromiso ganglionar linfático sugeridos en estudios previos. Esta información permitirá identificar un subgrupo de pacientes con bajo riesgo de CP candidatas a una cirugía menos radical en nuestra institución. Palabras clave: Cáncer del cuello uterino; Histerectomía; Escisión del ganglio linfático (fuente: DeCS BIREME). PARAMETRIAL INVOLVEMENT IN CERVICAL CANCER IB1 PATIENTS TREATED WITH RADICAL HYSTERECTOMY IN PERU ABSTRACTObjectives. To assess the frequency and factors associated with parametrial involvement (PI) in patients with cervical cancer IB1 who underwent radical hysterectomy (RH) at the National Institute of Neoplastic Diseases in Peru. Materials and methods. Cross-sectional study of 214 patients with cervical cancer IB1 undergoing RH with pelvic lymphadenectomy between 2007 and 2012. The population was compared with and without clinicopathological variables associated with PI such as age, tumor size, depth of infiltration, histological grade and pelvic lymph node involvement. Results. Ten patients (4.6%) had PI. Multivariate analysis showed that the depth of invasion (OR 8.37, p=0.029) and pelvic node involvement (OR 18.03; p=0.001) were all independent predictors of PI. The presence of tumor size ≤ 2 cm, invasion ≤ 10 mm, absence of lymphovascular permeation and absence of nodal involvement identified 97 patients at low risk of PI, none of whom had PI pathology. Conclusions. We confirmed the low frequency of PI in the cervical cancer IB1 subgroup and its association with the depth of invasion and lymph node involvement suggested in previous studies. This information will allow the identification of a subgroup of patients at low risk of PI for less radical surgery in our institution.

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A prospective surgical pathological study of stage I squamous carcinoma of the cervix: A Gynecologic Oncology Group study

Cited by 359 publications

References 7 publications

Sentinel node procedure in Ib cervical cancer: a preliminary series

Sentinel node procedure in Ib cervical cancer: a preliminary series

Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix

Compromiso parametrial en pacientes con cáncer de Cérvix IB-1 tratadas con histerectomía radical en Perú

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