Background and Aim: Contraception in the postpartum period is a significant problem. When used correctly, injectable hormonal contraceptives are one of the most reliable methods of contraception currently available. The purpose of the present study was to assess the effect of injectable DMPA as a short term contraceptive in immediate postpartum women. Patients and Methods: This prospective observational study was conducted on 130 postpartum women in the Gynaecology Department of Ayub Teaching Hospital, Abbottabad from December 2018 to December 2019. The study group of 130 postpartum women were given injectable DMPA 150 mg intramuscularly during discharge from hospital and after three months. The mother was subjected to a complete general physical examination. The need of exclusive breast feeding was emphasized. Fasting blood samples were collected for liver function testing (LFT), lipid profile, blood sugar, haemoglobin (Hb). About 130 postpartum women who were not taking any hormonal contraceptive were considered a control group. All the patients were followed-up for six weeks, three months, and six months. Data analysis was done using SPSS version 27. Results: The overall mean age of study group was 24.6±2.9 years with an age range 20 to 34 years.